ArticleInternational journal of biological sciences2025
Apelin facilitates integrin αvβ3 production and enhances metastasis in prostate cancer by activating STAT3 and inhibiting miR-8070.
Article in International journal of biological sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Macrophage-derived CTSZ promotes prostate cancer progression via αVβ3 integrin-mediated activation of the AKT/FOXO1/JUNB signaling axis.Cancer cell international · 2026Article
- lnc-ALX1-2:10 is a novel regulator that enhances proliferation, migration and invasion in prostate cancer cells.Scientific reports · 2026Article
- Article
- Potential impact ofInternational journal of medical sciences · 2026Article
- Betulin inhibits inflammatory factors synthesis in osteoarthritis synovial fibroblasts by suppressing the PI3K, Akt, and mTOR pathways and activating miR-5006-5p.International journal of medical sciences · 2026Article
- Potential influence of omentin-1 genetic variants on the clinicopathological features of patients with hepatocellular carcinoma.Journal of Cancer · 2026Article
- WISP-3 facilitates CCL4-dependent monocyte migration and M1 polarization in rheumatoid arthritis by inhibiting miR-6894-5p.International journal of medical sciences · 2026Article
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12 authors.
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Abstract
Prostate cancer is the most common cancer in men and is often associated with distant metastasis in its later stages. Cell surface receptors called integrins function as adhesion molecules that mediate both cell adhesion and motility. The adipokine apelin has been implicated in cancer progression and metastasis. However, the mechanisms by which apelin regulates integrin production and metastasis in prostate cancer remain unclear. Here, we found that apelin and integrin αvβ3 expression levels were elevated in prostate cancer samples compared to those in normal individuals. Apelin stimulation enhances integrin αvβ3-dependent prostate cancer migration. The activation of STAT3 and inhibition of miR-8070 via the MAPK pathway mediate apelin-facilitated integrin synthesis and cell motility. Importantly, our
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