ArticleToxicology reports2025
L-arginine supplement ameliorates dichlorvos-induced systemic inflammatory response and liver dysfunction in male wistar rats.
Article in Toxicology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dichlorvos (DDVP), a frequently used organophosphate insecticide, has been shown to cause systemic inflammation and liver damage via oxidative stress and inflammatory pathways. L-arginine, a semi-essential amino acid, has been shown to protect against oxidative damage and inflammation in a variety of animals. The study's main goal was to raise awareness of Dichlorvos's (DDVP) harmful effects on systemic inflammation and liver function, as well as L-arginine's possible mitigating impact. In order to assess the preventive benefits of L-arginine against induced liver dysfunction and systemic inflammation, liver tissue was selected for this investigation due to its vital role in detoxification and its high susceptibility to harm from toxic chemicals such as Dichlorvos. A total of 40 adult Wistar rats were separated into four groups: control, dichlorvos only, L-arginine only, and dichlorvos plus L-arginine. Dichlorvos was provided orally at a dose of 8 mg/kg body weight, whereas L-arginine was given orally at a dose of 100 mg/kg body weight for six weeks. The study investigated systemic inflammation markers (C-reactive protein, TNF-α, IL-6, and Caspase 3) as well as liver function markers (ALT, AST, ALP, albumin, total protein and gamma glutamyl). The findings revealed that dichlorvos significantly (p < 0.05) enhanced systemic inflammation and decreased (p < 0.05) liver function when compared to the control group. However, L-arginine supplementation greatly improved these effects by significantly (p < 0.05) lowering inflammatory indicators and restoring liver enzyme levels to normal. Histopathological findings validated L-arginine's protective function against dichlorvos-induced liver injury. These data indicate that L-arginine supplement may reduce the negative effects of dichlorvos on systemic inflammation and liver function, providing a possible therapeutic method for controlling organophosphate toxicity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.