ArticleFrontiers in plant science2025
Genome and transcriptome wide association study identify candidate genes regulating folate levels in maize.
Article in Frontiers in plant science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- High-Quality Genome Assemblies of Two Prototheca wickerhamii Strains.Scientific data · 2026Article
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6 authors.
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Abstract
Background: Maize ( Methods: A total of 380 maize kernels representing 190 maize inbred lines from China, Thailand, Mexico, and Peru were collected. RNA-seq was conducted on 380 maize kernel samples, and folate content was quantified using high-performance liquid chromatography (HPLC). The samples were stratified into high and low folate groups based on median folate values. Differentially expressed genes (DEGs) were identified between the two groups identified. Candidate genes associated with folate accumulation were further located by integrating transcriptome-wide association studies (TWAS) and genome-wide association studies (GWAS) analyses. Finally, quantitative real-time PCR (qRT-PCR) was employed to validate the expression patterns of these candidate genes. Results: A total of 137 DEGs that exhibited significant differences between the high-folate and low-folate groups were identified. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses revealed that these genes were significantly enriched in pathways related to phenylpropanoid biosynthesis, oxidoreductase activity, and stress response. GWAS identified 2,153 candidate genes associated with folate traits ( Conclusion: This study identifies key regulatory genes potentially influencing folate accumulation in maize and provides critical insights for the development of biofortified maize varieties with enhanced nutritional value.
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