Evidence map›Paper›PMID 40612505›Full record

ArticleiScience2025

Identification of novel macrophages and bone morphogenetic protein signals causing ectopic calcification and impairing muscle regeneration.

Linan Shi, Zhifeng He, Toru Hiraga, Ziyang Liu, Teruhito Yamashita, Rina Iwamoto, Toshihide Mizoguchi, Yuko Nakamichi, Yoshiaki Kubota, Nobuyuki Udagawa and 1 more

Abstract read
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. 15-PGDH inhibition promotes muscle repair and strength recovery during GLP-1 receptor agonist-induced weight loss.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Linan ShiGraduate School of Oral Medicine, Matsumoto Dental University, Shiojiri, Nagano 399-0781, Japan.
Zhifeng HeDepartment of Hard Tissue Research, Institute for Oral Science, Matsumoto Dental University, Shiojiri, Nagano 399-0781, Japan.
Toru HiragaDepartment of Histology and Cell Biology, Matsumoto Dental University, Shiojiri, Nagano 399-0781, Japan.
Ziyang LiuGraduate School of Oral Medicine, Matsumoto Dental University, Shiojiri, Nagano 399-0781, Japan.
Teruhito YamashitaDepartment of Hard Tissue Research, Institute for Oral Science, Matsumoto Dental University, Shiojiri, Nagano 399-0781, Japan.
Rina IwamotoDepartment of Hard Tissue Research, Institute for Oral Science, Matsumoto Dental University, Shiojiri, Nagano 399-0781, Japan.
Toshihide MizoguchiOral Health Science Center, Tokyo Dental College, Chiyoda-ku, Tokyo 101-0061, Japan.
Yuko NakamichiDepartment of Hard Tissue Research, Institute for Oral Science, Matsumoto Dental University, Shiojiri, Nagano 399-0781, Japan.
Yoshiaki KubotaDepartment of Anatomy, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan.
Nobuyuki UdagawaDepartment of Hard Tissue Research, Institute for Oral Science, Matsumoto Dental University, Shiojiri, Nagano 399-0781, Japan.
Yasuhiro KobayashiDepartment of Hard Tissue Research, Institute for Oral Science, Matsumoto Dental University, Shiojiri, Nagano 399-0781, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ectopic calcification is an abnormal regenerative response occurring in various tissues following injury, surgery, or genetic mutations. However, its underlying mechanisms remain unclear. By comparing three macrophage depletion methods using clodronate liposome, Csf1r neutralizing antibody, and macrophage-specific

Indexed as

Cellular physiologyMolecular biology

Identifiers

PMID40612505
PMCPMC12221681

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.