ArticleFrontiers in nutrition2025
Manganese exposure and its U-shaped relationship with diabetic retinopathy: analysis of NHANES 2011-2020.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Background: Although many studies have pointed to the role of manganese in various diseases. However, there are surprisingly few studies on the potential relationship between manganese and diabetic retinopathy (DR). The available literature fails to provide definitive conclusions regarding the directionality and strength of this particular association. Methods: The analytical cohort comprised 2,558 adults from NHANES 2011-2020 cycles. We employed binary logistic regression to evaluate manganese-DR associations, supplemented by subgroup analyses, nonparametric smoothing techniques, and propensity score weighting to address potential confounding. Results: Our multivariate model failed to find a significant linear relationship between manganese concentration and the likelihood of DR ( Conclusion: The manganese and DR relationship followed a U-shaped dose-response pattern. The least severe condition was observed at 7.66 μg/L, while the disease was aggravated at both insufficient and excessive concentrations.
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