Evidence map›Paper›PMID 40612316›Full record

ArticleFrontiers in nutrition2025

Lower dietary folate intake increases the risk of autoimmune thyroiditis.

Lijun Chen, Changjian Yan, Yingxuan Lin, Liqun Huang, Chunling Huang, Zhida Wei, Hongli Lin, Xiaohong Wu, Ruhai Lin, Zhengrong Jiang and 1 more

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In one paragraph

Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lijun Chen *Department of Endocrinology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, China.
Changjian Yan *Department of Hematology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, China.
Yingxuan Lin *School of Clinical Medicine, Fujian Medical University, Fuzhou, Fujian Province, China.
Liqun Huang *Department of Nuclear Medicine, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, China.
Chunling HuangDepartment of Electrocardiogram, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, China.
Zhida WeiInformation Center, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, China.
Hongli LinDepartment of Endocrinology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, China.
Xiaohong WuDepartment of Endocrinology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, China.
Ruhai LinDepartment of Endocrinology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, China.
Zhengrong JiangDepartment of Endocrinology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, China.
Huibin HuangDepartment of Endocrinology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Autoimmune thyroid diseases (AITDs) are a group of organ-specific autoimmune disorders resulting from the loss of immune tolerance, with autoimmune thyroiditis (AIT) being the most common phenotype. In recent years, folate, an essential nutrient, has been associated with the onset of various autoimmune diseases. However, the relationship between dietary folate intake and AIT remains unclear. Objective: This study seeks to explore the possible link between folate consumption and AIT. Methods: This study is based on the 2009-2010 National Health and Nutrition Examination Survey (NHANES) data to analyze the connection between folate consumption and the risk of AIT. A total of 2037 participants were included in the study. Based on TPOAb or TgAb levels, participants were classified into the AIT group ( Results: The analysis results indicate that the dietary folate intake of AIT patients was significantly lower than that of the non-AIT group (356.7 ± 172.4 vs. 396.1 ± 200.3mcg/day, Conclusion: This cross-sectional study is the first to explore the association between dietary folate consumption and the likelihood of developing AIT. The results suggest that lower dietary folate intake may be an independent factor contributing to AIT. It may provide new insights for the development of future dietary prevention strategies for AIT.

Indexed as

autoimmune thyroiditiscross-sectional studydietary folate intakenutritional epidemiologyrisk prediction model

Identifiers

PMID40612316
PMCPMC12221903

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