Evidence map›Paper›PMID 40612208›Full record

ReviewSage open pediatrics

Myocarditis Following COVID-19 Vaccine: What Did We Learn?

Joseph Abourjeili, Christelle Lattouf, Anthony Abou Mrad, Elio Salameh, Rana Zareef, Fadi Bitar, Mariam Arabi

Abstract readReview
In one paragraph

Review in Sage open pediatrics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Joseph AbourjeiliAmerican University of Beirut Medical Center, Beirut, Lebanon.
Christelle LattoufAmerican University of Beirut Medical Center, Beirut, Lebanon.
Anthony Abou MradAmerican University of Beirut Medical Center, Beirut, Lebanon.
Elio SalamehAmerican University of Beirut Medical Center, Beirut, Lebanon.ORCID https://orcid.org/0000-0001-7732-524X
Rana ZareefAmerican University of Beirut Medical Center, Beirut, Lebanon.
Fadi BitarAmerican University of Beirut Medical Center, Beirut, Lebanon.
Mariam ArabiAmerican University of Beirut Medical Center, Beirut, Lebanon.ORCID https://orcid.org/0000-0001-6895-1580

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The COVID-19 pandemic has had a profound global impact, with vaccination emerging as a key strategy for controlling the virus. However, concerns have arisen regarding potential cardiovascular side effects, particularly myocarditis following mRNA COVID-19 vaccination. This review examines the risk of post-vaccination myocarditis by analyzing over 40 studies. Findings indicate that myocarditis occurs most commonly within 2 to 4 days after the second dose, particularly in males aged 12 to 39 years. Proposed mechanisms include molecular mimicry and hypersensitivity reactions. Despite these concerns, most cases present with mild symptoms such as chest pain and dyspnea, resolving with supportive care. Importantly, the overall safety profile of COVID-19 vaccines remains high, with benefits significantly outweighing risks. Further multi-center studies are needed to fully understand the pathophysiology and mitigate potential adverse effects. No clinical trials were conducted for this review.

Indexed as

COVID-19mRNAmyocarditispandemicvaccine

Identifiers

PMID40612208
PMCPMC12220863

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.