Evidence map›Paper›PMID 40612200›Full record

ArticleSage open pediatrics

Subacute Sclerosing Panencephalitis in a North African Cohort: Findings From the Post-Measles Epidemic Era.

Meriem Ben Hafsa, Zouhour Miladi, Insaf Dkhil, Aida Rouissi, Abir Zioudi, Thouraya Ben Younes, Maha Jamoussi, Hanene Benrhouma, Sonia Nagi, Ilhem Ben Youssef Turki and 2 more

Abstract read
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In one paragraph

Article in Sage open pediatrics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Meriem Ben HafsaDepartment of Child and Adolescent Neurology, Research Laboratory LR18SP04, National Institute Mongi Ben Hmida of Neurology, La Rabta, Tunis, Tunisia.ORCID https://orcid.org/0000-0003-0022-7523
Zouhour MiladiDepartment of Child and Adolescent Neurology, Research Laboratory LR18SP04, National Institute Mongi Ben Hmida of Neurology, La Rabta, Tunis, Tunisia.
Insaf DkhilUniversity Tunis El Manar, Tunisia.
Aida RouissiDepartment of Child and Adolescent Neurology, Research Laboratory LR18SP04, National Institute Mongi Ben Hmida of Neurology, La Rabta, Tunis, Tunisia.
Abir ZioudiDepartment of Child and Adolescent Neurology, Research Laboratory LR18SP04, National Institute Mongi Ben Hmida of Neurology, La Rabta, Tunis, Tunisia.ORCID https://orcid.org/0009-0000-6705-6461
Thouraya Ben YounesDepartment of Child and Adolescent Neurology, Research Laboratory LR18SP04, National Institute Mongi Ben Hmida of Neurology, La Rabta, Tunis, Tunisia.ORCID https://orcid.org/0000-0002-1475-938X
Maha JamoussiDepartment of Child and Adolescent Neurology, Research Laboratory LR18SP04, National Institute Mongi Ben Hmida of Neurology, La Rabta, Tunis, Tunisia.ORCID https://orcid.org/0000-0003-3659-0594
Hanene BenrhoumaDepartment of Child and Adolescent Neurology, Research Laboratory LR18SP04, National Institute Mongi Ben Hmida of Neurology, La Rabta, Tunis, Tunisia.
Sonia NagiUniversity Tunis El Manar, Tunisia.
Ilhem Ben Youssef TurkiDepartment of Child and Adolescent Neurology, Research Laboratory LR18SP04, National Institute Mongi Ben Hmida of Neurology, La Rabta, Tunis, Tunisia.
Hedia KlaaDepartment of Child and Adolescent Neurology, Research Laboratory LR18SP04, National Institute Mongi Ben Hmida of Neurology, La Rabta, Tunis, Tunisia.ORCID https://orcid.org/0000-0002-0135-4121
Ichraf KraouaDepartment of Child and Adolescent Neurology, Research Laboratory LR18SP04, National Institute Mongi Ben Hmida of Neurology, La Rabta, Tunis, Tunisia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Subacute sclerosing panencephalitis (SSPE) is a rare, fatal encephalitis caused by chronic measles virus infection. Its recent resurgence, particularly after measles epidemics, underscores the need for vigilance in children. This study describes the clinical, paraclinical, therapeutic features, and prognosis of SSPE in 15 patients. Initial symptoms included gait disturbances, psychomotor regression, and behavioral changes. Neurological examination revealed cognitive decline, visual impairment, hypotonia, pyramidal signs, ataxia, and movement disorders. Electroencephalogram showed periodic delta wave complexes, while brain imaging identified subcortical and periventricular white matter (WM) lesions, brainstem involvement, and progressive cortical-subcortical atrophy on follow-up. All patients tested positive for anti-measles immunoglobulins G in cerebrospinal fluid and blood. Despite treatment, rapid clinical deterioration led to akinetic mutism and neurovegetative symptoms. This study alerts clinicians and radiologists to consider SSPE in children presenting with subacute cognitive decline, myoclonus and epilepsy with periodic complexes, associated with specific WM changes, particularly in the post-epidemic period.

Indexed as

childrenencephalitisepilepsymeaslesmyoclonus- neuroimaging

Identifiers

PMID40612200
PMCPMC12220887

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.