ArticleSage open pediatrics
Clinical Characteristics and Outcomes of Severe Adverse Reactions to Bacille Calmette-Guérin (BCG) Vaccination in China: A Single-Center Retrospective Study.
Article in Sage open pediatrics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
Objectives: This study investigated the clinical features, treatment approaches, and outcomes of severe Introduction: BCG is the only available vaccine for tuberculosis (TB) prevention but can cause serious complications such as local abscesses, lymphadenitis, and disseminated BCG. Research on their management in China is limited. Methods: This observational study reviewed 95 children with severe BCG-related complications treated at a tuberculosis-specialized hospital in Guangdong, China (2016-2020). Of these, 33 (34.7%) had injection site reactions, 55 (57.9%) developed lymphadenitis with 31 suppurative cases, and 7 (7.4%) had disseminated BCG. All deep abscesses and suppurative lymphadenitis were successfully treated with surgery and anti-tubercular therapy. Two disseminated BCG cases had primary immunodeficiency, and 1 of them died. Conclusion: Most local reactions respond to conservative treatment. Surgery combined with anti-tubercular therapy is effective for suppurative lymphadenitis. Early immunological evaluation is essential for disseminated disease.
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