Evidence map›Paper›PMID 40612135›Full record

ArticleFood science & nutrition2025

Capsaicinoid Glucoside Attenuates Lipid Accumulation in HepG2 Cells Through TRPV1/AMPK-Dependent Signaling Pathway.

Abdeen Elkhedir, Alsadig Yahya, Eihab H Jadelrab, Mazin Mohamed Salih, Amgad Albahi, Yassin Haran, Mamoun A Homaida, Hammad Hamed, Xiaoyun Xu

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In one paragraph

Article in Food science & nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Abdeen ElkhedirAgro-Industries Institute, Industrial Research and Consultancy Centre (IRCC) Khartoum Sudan.ORCID https://orcid.org/0009-0003-7913-9418
Alsadig YahyaDepartment of Food Science and Technology, Faculty of Agriculture and Natural Resources University of Bakht Al-Ruda Ed Dueim Sudan.
Eihab H JadelrabFood Science and Technology College of Agricultural Studies, Sudan University of Science & Technology Khartoum Sudan.
Mazin Mohamed SalihAgro-Industries Institute, Industrial Research and Consultancy Centre (IRCC) Khartoum Sudan.
Amgad AlbahiNational Food Research Centre Ministry of Agriculture and Natural Resources Khartoum Sudan.ORCID https://orcid.org/0000-0002-5249-1484
Yassin HaranDepartment of Food Science and Technology, Faculty of Agriculture and Natural Resources University of Bakht Al-Ruda Ed Dueim Sudan.
Mamoun A HomaidaDepartment of Food Science and Technology, Faculty of Agriculture and Natural Resources University of Bakht Al-Ruda Ed Dueim Sudan.
Hammad HamedNational Food Research Centre Ministry of Agriculture and Natural Resources Khartoum Sudan.
Xiaoyun XuCollege of Food Science and Technology Huazhong Agricultural University Wuhan China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metabolic disorders associated with excessive lipid accumulation pose a significant global health challenge. Capsaicinoid glucoside (CG), a novel water-soluble derivative of capsaicin, offers improved bioavailability and reduced pungency. In this study, we evaluated the lipid-lowering effects of CG and its underlying mechanisms in oleic acid (OA)-induced HepG2 cells. Treatment with 100 μg/mL CG significantly reduced triglyceride (TG) levels by 60.7% and total cholesterol (TC) levels by 34.4%, compared to the OA group. CG also markedly decreased intracellular reactive oxygen species (ROS) and reduced lipid droplet accumulation, as confirmed by Oil Red O staining. At the molecular level, CG significantly upregulated TRPV1 and AMPK gene and protein expression, while downregulating lipogenic markers such as SREBP-1c and FASN. It also increased the expression of lipid oxidation-related genes, including PPARδ. Molecular docking revealed stable interactions of CG with both TRPV1 and AMPK, supporting their roles in the observed metabolic effects. These findings suggest that CG exerts its lipid-lowering and antioxidant effects via the TRPV1/AMPK signaling pathway and highlight its potential application as a functional food component or therapeutic supplement for improving hepatic lipid metabolism.

Indexed as

AMPKCapsaicinoid glucosidecellular signaling pathwayHepG2 cellslipid metabolismTRPV1

Identifiers

PMID40612135
PMCPMC12221993

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.