ReviewFrontiers in cell and developmental biology2025
Weibel-Palade bodies - secretory organelles at the interface of inflammation and hemostasis.
Review in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Subunits of adaptor protein complex-1 make distinct contributions to the virulence ofInfection and immunity · 2026Article
- Cerebral venous blood flow regulates intracerebral pressure and brain clearance via meningeal lymphatic vessels.Nature neuroscience · 2026Article
- Development of a Photostable pH Biosensor Based on mStayGold.Chembiochem : a European journal of chemical biology · 2026Article
- Mechanistic insights into cargo sorting and export from the Golgi apparatus.Nature reviews. Molecular cell biology · 2025Review
- Platelets mediate neutrophil infiltration and exacerbate liver injury and sinusoidal endothelial cell damage after a severe acetaminophen overdose in mice.Archives of toxicology · 2025Article
- Immune effector cell-associated neurotoxicity syndrome: integrative mechanisms, predictive biomarkers, and translational pathways for prevention in CAR T-cell therapy.Frontiers in neurologyReview
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Authors and funding
2 authors.
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Abstract
Weibel-Palade bodies (WPB) are lysosome-related, secretory organelles unique to vascular endothelial cells. They serve as storage organelles for the pro-thrombotic and hemostatic glycoprotein von-Willebrand factor (VWF) as well as numerous other proteins involved in regulating local inflammatory responses and coagulation processes. WPB undergo a complex formation and maturation process mainly dictated by the post-translational maturation of VWF itself. They are born at the trans-Golgi network and then move on microtubules to the cell periphery where they are anchored at the actin cortex to await signals triggering their evoked exocytosis. During this process, VWF undergoes significant compaction that results in an elongated, cigar-like shape of the organelle. WPB also receive material from the endosomal system although the trafficking routes involved here have not been fully unveiled. Exocytosis of WPB is induced by various agonists signaling through intracellular Ca
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