ArticleCurrent developments in nutrition2025
Nighttime Pistachio Consumption Alters Stool Microbiota Diversity and Taxa Abundance Compared with Education to Consume 1-2 Carbohydrate Exchanges (15-30 grams) over 12 Weeks in Adults with Prediabetes: A Secondary Analysis from a Randomized Crossover Trial.
Article in Current developments in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04056208 (The Effect of Pistachios on Risk Factors for Cardiometabolic Disease in Individuals With Pre-diabetes), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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The Effect of Pistachios on Risk Factors for Cardiometabolic Disease in Individuals With Pre-diabetes: a Randomized, Cross-over Study
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8 authors.
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Abstract
Background: Prior research has demonstrated that pistachio intake influences gut microbiota composition; however, there has been limited investigation of pistachio-related gut microbial modulation in populations with impaired glycemia. Objectives: The aim was to examine the effect of nighttime pistachio intake for 12 wk on the stool microbiota of adults with prediabetes [fasting plasma glucose (FPG) ≥100 mg/dL and ≤125 mg/dL]. Methods: A secondary analysis of data from a single-blind, 2-period, randomized crossover trial was conducted. Participants were provided with 57 g/d of dry roasted unsalted pistachios to consume as a nighttime snack or provided education to consume 1-2 carbohydrate (CHO; 15-30 g) exchanges (usual care) as a nighttime snack for 12 wk. Stool samples were collected at the beginning and the end of each condition and analyzed with 16S ribosomal ribonucleic acid gene sequencing. Taxonomic diversity was tested with linear mixed models (LMMs) and permutational analysis of variance of Bray-Curtis and weighted Unifrac dissimilarity indices. Taxonomic abundance by condition was tested using LMMs with Benjamini-Hochberg multiple testing correction. Results: The analytical sample included 51 participants (37% female, 49 ± 10 y, 31.5 ± 4 kg/m Conclusions: In adults with prediabetes, intake of 57 g/d of pistachios as a nighttime snack altered stool microbial community diversity and composition compared with a CHO-rich snack, providing evidence of stool microbial effects with pistachio consumption. Trial registration number: This study was registered at clinicaltrials.gov as NCT04056208.
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