Evidence map›Paper›PMID 40612047›Full record

ArticleCurrent developments in nutrition2025

Low-Carbohydrate Diet Patterns That Favor High-Quality Carbohydrates Are Associated with Beneficial Long-Term Changes in Biomarkers of Inflammation and Oxidative Stress in the Framingham Offspring Cohort.

Ghaida F Aloraini, Nicola M McKeown, Gail T Rogers, Sai Krupa Das, Alice H Lichtenstein, Paul F Jacques

Abstract read
In one paragraph

Article in Current developments in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ghaida F AlorainiUSDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, United States.
Nicola M McKeownFriedman School of Nutrition Science and Policy, Tufts University, Boston, MA, United States.
Gail T RogersUSDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, United States.
Sai Krupa DasUSDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, United States.
Alice H LichtensteinUSDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, United States.
Paul F JacquesUSDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Low-carbohydrate diet (LCD) patterns have been studied as a potential strategy to reduce chronic inflammation. Evidence remains equivocal, likely because of differences in the quality of carbohydrate sources among LCD patterns. Objectives: To prospectively examine the associations between LCD patterns varying in carbohydrate quality, and changes of inflammation and oxidative stress biomarkers. Methods: Among Framingham Offspring Study participants ( Results: HQ-LCDS was inversely associated with change in the inflammation and oxidative stress score (mean ± SE in Q1: 0.24 ± 0.16, Q5: -0.27 ± 0.16; Conclusions: LCD patterns that preserved high-quality carbohydrates while replacing low-quality carbohydrates sources, such as refined grains and added sugars, with fat and protein were inversely associated with inflammation and oxidative stress score, potentially lowering chronic disease risk.

Indexed as

agingcarbohydrate qualitychronic inflammationFramingham Heart Studylow-carbohydrate dietoxidative stress

Identifiers

PMID40612047
PMCPMC12221638

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.