Evidence map›Paper›PMID 40612004›Full record

ArticleBiochemistry and biophysics reports2025

Two-pore domain potassium channel TREK-1 contributes to arachidonic acid-induced Ca

Battulga Khaltar, Futoshi Toyoda, Kosuke Kumagai, Takafumi Yayama, Batchimeg Tsedenbal, Kohei Umeda, Hideki Saito, Naranbat Lkhagvasuren, Mitsuhiko Kubo, Shinji Imai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry and biophysics reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Battulga KhaltarDepartment of Orthopaedic Surgery, Shiga University of Medical Science, Otsu, Shiga, 520-2192, Japan.
Futoshi ToyodaCenter Research Laboratory, Shiga University of Medical Science, Otsu, Shiga, 520-2192, Japan.
Kosuke KumagaiDepartment of Orthopaedic Surgery, Shiga University of Medical Science, Otsu, Shiga, 520-2192, Japan.
Takafumi YayamaDepartment of Orthopaedic Surgery, Shiga University of Medical Science, Otsu, Shiga, 520-2192, Japan.
Batchimeg TsedenbalDepartment of Orthopaedic Surgery, Shiga University of Medical Science, Otsu, Shiga, 520-2192, Japan.
Kohei UmedaDepartment of Orthopaedic Surgery, Shiga University of Medical Science, Otsu, Shiga, 520-2192, Japan.
Hideki SaitoDepartment of Orthopaedic Surgery, Shiga University of Medical Science, Otsu, Shiga, 520-2192, Japan.
Naranbat LkhagvasurenDepartment of the Traumatology and Orthopedics, School of Medicine, Mongolian National University of Medical Sciences, Ulaanbaatar, 14210, Mongolia.
Mitsuhiko KuboDepartment of Sports and Musculoskeletal Medicine, Shiga University of Medical Science, Otsu, Shiga, 520-2192, Japan.
Shinji ImaiDepartment of Orthopaedic Surgery, Shiga University of Medical Science, Otsu, Shiga, 520-2192, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human fibroblast-like synovial cells (hFLSs) are essential in maintaining the structural integrity of the articular cartilage and promoting joint inflammation. These cells are highly responsive to various physical and chemical stimuli, many of which influence cellular processes through intracellular Ca

Indexed as

Arachidonic acidCalcium signalingFibroblast-like synovial cells (hFLSs)K2P channelsSpadinTREK-1

Identifiers

PMID40612004
PMCPMC12226111

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.