ArticleChemical science2025
Multifunctional chiral silanol ligands for enantioselective catalysis.
Article in Chemical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
We report transition metal catalysis using novel chiral metal-chelating ligands featuring a silanol coordinating group and peptide-like aminoamide scaffold. The catalytic properties of the silanol ligand are demonstrated through an enantioselective Cu-catalyzed N-H insertion affording unnatural amino acid derivatives in high selectivity. Our investigations into the silanol coordination mode include DFT calculations, ligand structure investigations, and X-ray structure analyses, which support the formation of an H-bond stabilized silanol-chelating copper carbenoid complex. A π-π stacking interaction revealed by DFT calculations is proposed to enable selectivity for aryl diazoacetate substrates, overcoming some of the traditional limitations of using these substrates.
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