Evidence map›Paper›PMID 40611908›Full record

ArticlebioRxiv : the preprint server for biology2025

High-throughput genetic mapping discovers novel zinc toxicity response loci in

Katherine M Hanson, Anthony D Long, Stuart J Macdonald

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Katherine M HansonDepartment of Molecular Biosciences and Center for Genomics, University of Kansas, 1200 Sunnyside Avenue, Lawrence, KS 66045, USA.
Anthony D LongDepartment of Ecology and Evolutionary Biology, University of California at Irvine, Irvine, CA 92697, USA.
Stuart J MacdonaldDepartment of Molecular Biosciences and Center for Genomics, University of Kansas, 1200 Sunnyside Avenue, Lawrence, KS 66045, USA.ORCID 0000-0002-9421-002X

Funding

Mentoring CoreP20GM103418 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Douglas E Wright · 2012 to 2026
$63.0M
Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
A Resource for the Genetic Dissection of Complex TraitsR01OD034064 · OD · UNIVERSITY OF KANSAS LAWRENCE · PI ANTHONY Douglas LONG, Stuart John Macdonald · 2023 to 2026
$2.4M
Toxicogenomics of metal response in genetically-variable DrosophilapopulationsR01ES029922 · NIEHS · UNIVERSITY OF KANSAS LAWRENCE · PI MACDONALD, STUART JOHN · 2019 to 2021
$682k
NIEHS NIH HHS R01 ES029922NIGMS NIH HHS P20 GM103418NIH HHS P40 OD018537NIH HHS R01 OD034064
6 · The paper itself

Abstract

Heavy metals are a widespread environmental contaminant, and even low levels of some metals can disrupt cellular processes and result in DNA damage. However, the consequences of metal exposure are variable among individuals, with susceptibility to metal toxicity representing a complex trait influenced by genetic and non-genetic factors. To uncover toxicity response genes, and better understand responses to metal toxicity, we sought to dissect resistance to zinc, a metal required for normal cellular function, which can be toxic at high doses. To facilitate efficient, powerful discovery of Quantitative Trait Loci (QTL) we employed extreme, or X-QTL mapping, leveraging a multiparental, recombinant

Indexed as

bulked phenotypingDSPRExtreme QTL mappingzinc toxicity

Identifiers

PMID40611908
PMCPMC12224547

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.