Evidence map›Paper›PMID 40611876›Full record

ArticleAdvances in radiation oncology2025

Esophageal Circumferential Dose-Length Histogram Parameters to Predict Dysphagia in Patients Receiving Thoracic Radiation Therapy: A Single-Institution Experience.

Andrea Brown, Chen Hu, Suqi Ke, Peijin Han, Russell Hales, Todd McNutt, Siyao Li, Claire Snyder, Shing Lee, Khinh Ranh Voong

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Article in Advances in radiation oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Andrea BrownDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland.
Chen HuDivision of Quantitative Sciences, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Suqi KeDivision of Quantitative Sciences, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Peijin HanDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan.
Russell HalesDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland.
Todd McNuttDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland.
Siyao LiDivision of Quantitative Sciences, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Claire SnyderDepartments of Medicine, Oncology, and Health Policy & Management, Johns Hopkins Schools of Medicine and Public Health, Baltimore, Maryland.
Shing LeeDepartment of Biostatistics, Mailman School of Public Health, Columbia University Medical Center, New York, New York.
Khinh Ranh VoongDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Chemoradiation for locally advanced non-small cell lung cancer can cause severe esophagitis. Techniques to spare the contralateral esophagus may mitigate toxicity, but traditional dose-volume histograms (DVH) do not capture the degree of circumferential irradiation. We evaluated dose-length histogram (DLH) parameters as predictors of dysphagia compared with DVH metrics. Methods: We retrospectively reviewed patients treated with definitive thoracic radiation therapy from 2019 to 2023. Descriptive statistics described the cohort. Clinician-reported (National Cancer Institute Common Terminology Criteria for Adverse Events [CTCAE] v.4) and patient-reported outcomes (PRO)-CTCAE v.1 dysphagia within 120 days of treatment start were collected prospectively. The McNemar test compared dichotomized scores. The length of esophageal full-circumferential (L Results: Of 107 patients, 86.9% (93) had non-small cell lung cancer, all received ≥60 Gy (median, 63 Gy; range, 60-70 Gy), and 94.4% (101) received concurrent chemotherapy. Patients and physicians reported rates of grade ≥2 dysphagia differently: 17 (15.9%) and 6 (5.6%), respectively ( Conclusion: Esophageal DLH metrics assessing partial- or full-circumferential esophageal irradiation, specifically L

Identifiers

PMID40611876
PMCPMC12221621

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