Observational studyClinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Distinctive Features of Rotational Thromboelastometry in Patients with Infective Endocarditis Undergoing on-Pump Cardiac Surgery: A Retrospective Propensity Score-matched Observational Study.
Observational study in Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BackgroundThe haemostatic system plays a role in development of valvular vegetations and systemic activation of coagulation, contributing to both thrombosis and consumption coagulopathy. Patients with infective endocarditis undergoing valvular surgery pose unique challenges to the surgical team. Rotational thromboelastometry (ROTEM), a point-of-care viscoelastic clotting test, can help assess coagulation and guide therapy. This retrospective propensity score-matched study explores ROTEM's distinctive features in endocarditis patients compared to others undergoing cardiac surgery.Materials and MethodsA retrospective analysis was performed on patients undergoing valvular surgery between May 31, 2022, and August 31, 2024. ROTEM assessments were conducted during extracorporeal circulation and post-heparin reversal. The study group consisted of patients with endocarditis, while propensity score matching created a control group of patients without endocarditis. The primary outcome was on-pump ROTEM results; secondary outcomes included utilisation of red blood cells (pRBC), fibrinogen concentrate (FC), prothrombin complex concentrate (PCC), fresh frozen plasma (FFP), and platelets.ResultsIn both groups (23 patients each), endocarditis patients had prolonged EXTEM clotting times (136 vs 96 s,
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