Evidence map›Paper›PMID 40611620›Full record

ArticleCerebral cortex (New York, N.Y. : 1991)2025

Structural and functional attention network connectivity in relation to visual selective attention dysfunction in cerebral visual impairment.

Marie Drottar, Claire E Manley, Negin Nadvar, Howard J Cabral, Peter J Bex, Lotfi B Merabet, Corinna M Bauer

Abstract read
In one paragraph

Article in Cerebral cortex (New York, N.Y. : 1991), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marie DrottarLaboratory of Neuroimaging and Vision Science, Department of Radiology, Massachusetts General Hospital, 125 Nashua Street, Boston, MA 02114, United States.
Claire E ManleyLaboratory of Visual Neuroplasticity, Department of Ophthalmology, Massachusetts Eye and Ear, 20 Staniford Street, Boston, MA 02114, United States.
Negin NadvarLaboratory of Neuroimaging and Vision Science, Department of Radiology, Massachusetts General Hospital, 125 Nashua Street, Boston, MA 02114, United States.
Howard J CabralDepartment of Biostatistics, Boston University School of Public Health, 801 Massachusetts Avenue, Boston, MA 02118, United States.
Peter J BexDepartment of Psychology, Northeastern University, 125 Nightingale Hall, Boston, MA 02115, United States.
Lotfi B MerabetLaboratory of Visual Neuroplasticity, Department of Ophthalmology, Massachusetts Eye and Ear, 20 Staniford Street, Boston, MA 02114, United States.ORCID 0000-0002-8094-9536
Corinna M BauerLaboratory of Neuroimaging and Vision Science, Department of Radiology, Massachusetts General Hospital, 125 Nashua Street, Boston, MA 02114, United States.ORCID 0000-0001-9407-4657

Funding

Thalamo-cortical circuitry in PVLR01EY030877 · NEI · MASSACHUSETTS GENERAL HOSPITAL · PI BAUER, CORINNA M · 2020 to 2024
$2.1M
NEI NIH HHS R01 EY030877
6 · The paper itself

Abstract

Individuals with cerebral visual impairment (CVI) often demonstrate difficulties with visual selective attention; however, the underlying neural mechanisms remain unclear. In this study, we investigated whether structural and functional connectivity between and within the attention networks, thalamus, and early visual areas is differentially associated with performance on a conjunction search task in participants with CVI as compared to controls. Data from 26 participants was collected and analyzed (10 CVI, four female, 17.4 years, 5.38 s.d., 16 control, 10 female, 22.25 years, 4.25 s.d.). White matter tracts associated with the dorsal and ventral attention networks as well as structural and functional connectivity matrices of the dorsal and ventral attention networks were generated for each participant. Group differences in conjunction search outcomes, tract volume, and network connectivity strength were evaluated. General linear models were used to investigate the relationship between neuroimaging predictor variables and each of the four conjunction search primary outcomes. All analyses were adjusted for age and verbal cognition. In the CVI group impaired visual search was associated with weaker structural and stronger functional connectivity, while in the control group the opposite effect was observed. Together, these results suggest that functional over-recruitment may be a maladaptive compensatory mechanism.

Indexed as

AttentionNerve NetVision DisordersVisual PerceptionAdolescentAdultFemaleHumansMagnetic Resonance ImagingMaleNeural PathwaysWhite MatterYoung Adultcerebral visual impairment (CVI)diffusion tractographydorsal attention networkselective visual attentionventral attention network

Identifiers

PMID40611620
PMCPMC12336986

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.