Evidence map›Paper›PMID 40611572›Full record

ArticlePhysiological reports2025

Obstructive sleep apnea severity and pathophysiological traits in overlap syndrome: Insights from the SNOOzzzE cohort.

Janna Raphelson, Ana Sanchez-Azofra, Jeremy E Orr, Gabriela Parra, Lana McGinnis, Alexis Salinas, Steven Luu, Scott A Sands, Ali Azarbarzin, Robert L Owens and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Janna RaphelsonDivision of Pulmonary, Critical Care, Sleep Medicine and Physiology, University of California, San Diego (UCSD), San Diego, California, USA.ORCID 0000-0002-8680-2586
Ana Sanchez-AzofraDivision of Pulmonary, Critical Care, Sleep Medicine and Physiology, University of California, San Diego (UCSD), San Diego, California, USA.
Jeremy E OrrDivision of Pulmonary, Critical Care, Sleep Medicine and Physiology, University of California, San Diego (UCSD), San Diego, California, USA.
Gabriela ParraDivision of Pulmonary, Critical Care, Sleep Medicine and Physiology, University of California, San Diego (UCSD), San Diego, California, USA.
Lana McGinnisDivision of Pulmonary, Critical Care, Sleep Medicine and Physiology, University of California, San Diego (UCSD), San Diego, California, USA.
Alexis SalinasDivision of Pulmonary, Critical Care, Sleep Medicine and Physiology, University of California, San Diego (UCSD), San Diego, California, USA.
Steven LuuDivision of Pulmonary, Critical Care, Sleep Medicine and Physiology, University of California, San Diego (UCSD), San Diego, California, USA.
Scott A SandsDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Ali AzarbarzinDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Robert L OwensDivision of Pulmonary, Critical Care, Sleep Medicine and Physiology, University of California, San Diego (UCSD), San Diego, California, USA.
Jose M MarinHospital Universitario Miguel Servet, IIS Aragón-CIBERES and Department of Medicine, University of Zaragoza, Zaragoza, Spain.
Atul MalhotraDivision of Pulmonary, Critical Care, Sleep Medicine and Physiology, University of California, San Diego (UCSD), San Diego, California, USA.
Christopher N SchmicklDivision of Pulmonary, Critical Care, Sleep Medicine and Physiology, University of California, San Diego (UCSD), San Diego, California, USA.

Funding

UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
San Diego Clinical and Translational Research InstituteUL1TR000100 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S · 2012 to 2015
$19.7M
Is Obstructive Sleep Apnea Important in the Development of Alzheimer's DiseaseR01AG063925 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2020 to 2024
$3.7M
Underlying mechanisms of obesity-induced obstructive sleep apneaR01HL148436 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Atul Malhotra · 2020 to 2026
$3.4M
Phenotyping Mechanistic Pathways for Adverse Health Outcomes in Sleep ApneaR01HL153874 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI AZARBARZIN, ALI · 2020 to 2024
$3.3M
Sleep Apnea Endophenotypes: One Size Does Not Fit AllR01HL154926 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2021 to 2025
$3.3M
The cardiovascular consequences of sleep apnea plus COPD (Overlap syndrome)R01HL166485 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Atul Malhotra · 2023 to 2026
$3.1M
VentNet: A Real-Time Multimodal Data Integration Model for Prediction of Respiratory Failure in Patients with COVID-19R01HL157985 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL, NEMATI, SHAMIM · 2022 to 2025
$2.9M
Acetazolamide to Improve Clinically Important Outcomes in Obstructive Sleep Apnea Patients with a High Loop Gain EndotypeK23HL161336 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Christopher Nikolaus Schmickl · 2022 to 2026
$863k
The Impact of Sleep Disordered Breathing in People who use OpioidsK23HL151880 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ORR, JEREMY ELLIOT · 2021 to 2025
$849k
The Left and Right Ventricles in Sleep Apnea with COPDF32HL176079 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RAPHELSON, JANNA · 2024 to 2025
$167k
Alfonso Martin Escudero Foundation (FUNDAME)American Heart Association (AHA) CDA#940501American Heart Association-American Stroke Association 940501ATS AspireClinical and Translational Science Awards (CTSA) Program UL1TR000100Clinical and Translational Science Awards (CTSA) Program UL1TR001442HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) F32HL176079HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) K23HL161336HHS | NIH | NHLBI | NHLBI Division of Intramural Research (DIR) AASMF (287 SR22)HHS | NIH | NHLBI | NHLBI Division of Intramural Research (DIR) K23HL151880HHS | NIH | NHLBI | NHLBI Division of Intramural Research (DIR) NIH (R01HL153874)instituto salud carlos III PI12/02175instituto salud carlos III PI15/01940instituto salud carlos III PI18/01524NCATS NIH HHS UL1 TR000100NCATS NIH HHS UL1 TR001442NHLBI NIH HHS F32 HL176079NHLBI NIH HHS K23 HL151880NHLBI NIH HHS K23 HL161336NHLBI NIH HHS L30 HL175771NHLBI NIH HHS R01 HL148436NHLBI NIH HHS R01 HL153874NHLBI NIH HHS R01 HL154926NHLBI NIH HHS R01 HL157985NHLBI NIH HHS R01 HL166485NIA NIH HHS R01 AG063925
6 · The paper itself

Abstract

The overlap syndrome (OVS), defined as coexisting chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA), is linked to worse outcomes than either condition alone. Patients with COPD and OSA may have fewer obstructive events, but underlying mechanisms remain unclear. Using a large clinical cohort, we tested the hypothesis that OSA severity and pathophysiological traits differ in OVS versus OSA-alone. Data from the SNOOzzzE cohort (3319 adults with in-laboratory polysomnography 2017-2019) were used. OVS patients were identified through chart review and matched to OSA-only patients (3:1) by age, sex, and body mass index. OSA severity was assessed using apnea hypopnea index (AHI), hypoxic burden (HB), and T90 (%time with SpO

Indexed as

Sleep Apnea, ObstructiveAdultAgedCohort StudiesFemaleHumansMaleMiddle AgedPolysomnographySeverity of Illness Indexchronic obstructive pulmonary diseaseendotypesobstructive sleep apnea

Identifiers

PMID40611572
PMCPMC12231188

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.