ArticleJournal of the American Heart Association2025
Interplay of Acquired Risk Factors, Age, and Genetic Predisposition in Incident Stroke: A Prospective Cohort Study.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Deep Vein Thrombosis Prevention in Acute Ischemic Stroke Patients with Lower Limb Paralysis: A Narrative Review.Journal of clinical medicine · 2026Review
- Targeting the Biology of Aging in Cerebrovascular Disease: Inflammation, Metabolism, Senescence, and Regeneration.International journal of molecular sciences · 2026Review
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStroke is the leading cause of disability and death worldwide, and its pathogenesis involves various risk factors. This study aimed to investigate the associations between acquired risk factors, age, and genetic predisposition in the incidence of stroke. METHODS AND
resultsWe analyzed 404 873 participants (age, mean±SD, 56.46±8.10 years; 45.97% men) from the UK Biobank cohort, all without a history of stroke at baseline and with complete information on risk factors. Hazard ratios and population-attributable risk percentages for incident stroke were calculated for 21 risk factors, including 3 social determinants, 8 unhealthy behaviors, 4 metabolic factors, 5 clinical comorbidities, and 1 genetic risk score. Participants were stratified by age and genetic risk. During a 4.8 million person-year follow-up, 8287 participants (2.05%) experienced a stroke. Metabolic factors, particularly hypertension, were key contributors to stroke risk across all age and genetic groups (population-attributable risk percentages, 26.53-38.63 and 28.05-37.09). Stroke risk due to overall metabolic factors increased with higher genetic risk (population-attributable risk percentages, 28.05 in low-risk and 37.09 in high-risk groups). The effects of certain risk factors, such as dietary risk and hypertension, were more pronounced in participants with higher genetic risk. The contributions of social factors and clinical comorbidities to stroke risk were relatively low across genetic risk groups.
conclusionsMetabolic factors, especially hypertension, are critical targets for stroke prevention across diverse age and genetic risk profiles. Tailored prevention strategies that address modifiable risk factors, considering individual age and genetic predisposition, have the potential to significantly reduce stroke incidence.
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