ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Regenerative Hair Pigmentation via Skin Organoids: Adaptive Patterning Mediated by Collagen VI and Semaphorin 3C.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Recent Advances in Genetically Engineered Mouse Models of Melanoma: Insights into Tumor Initiation and Oncogenic Signaling Pathways.International journal of stem cells · 2026Review
- [Research advances on the application of skin appendage organoids in wound repair].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2026Review
- [Skin organoids: an emerging platform from three-dimensional construction to regenerative application].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2026Review
- Study on the Mechanism ofPharmaceuticals (Basel, Switzerland) · 2026Article
- SIRT1 regulates dermal fibroblast senescence via impaired deacetylase function and mitochondrial dysfunction during skin aging induced by chronic oral cadmium exposure.Frontiers in public health · 2026Article
- Hair follicle organoids: advances in construction, applications, and translational challenges.Frontiers in cell and developmental biology · 2026Review
- Toward system-level integration of organoids for regenerative medicine.Burns & trauma · 2026Review
- Single-Cell RNA-Seq Reveals a Glycolysis-Biased EMT State in Keloid Keratinocytes That Amplifies the Pro-Inflammatory and Fibrotic Microenvironment.Journal of inflammation research · 2026Article
- From a stem-cell-centered to a niche-centered view: the core role of collagen networks in hair loss and hair follicle miniaturization.Frontiers in cell and developmental biology · 2026Review
- Regenerative Hair Pigmentation via Skin Organoids: Adaptive Patterning Mediated by Collagen VI and Semaphorin 3C.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Impact of Psychological Stress-Derived Hormones and Cytokines on Immune Cell Profiles in Vitiligo: Toward Improved Peripheral Blood Simulation in Animal Models.Clinical, cosmetic and investigational dermatology · 2025Review
Corrections and comments
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Authors and funding
18 authors.
Funding
Abstract
The color patterns of mammalian fur are determined by melanocytes' ability to respond to and adapt to microenvironmental cues. However, these patterns can be lost following injury or under pathological conditions, and the underlying biological mechanisms remain poorly understood. In this study, reconstituted hair-bearing skin is generated using skin organoids derived from dissociated epidermal cells, dermal cells, and melanocyte progenitors. The reconstituted skin exhibited pigmented hair patterns. By investigating the molecular cues involved in re-establishing pigment patterns, it is demonstrated that this process is regulated through a two-step mechanism. First, during skin organoid culture, signaling from dermal fibroblasts to melanocytes via the COL6A3-CD44 pathway promotes the early maintenance of organotypic melanocytes. Subsequently, during hair follicle morphogenesis after skin organoid transplantation, signaling from the bulge to melanocytes via the SEMA3C-NRP1 pathway regulates microtubule stability. This regulation guides melanocytes to migrate to their bulge stem cell niche, thereby enhancing hair pigmentation by promoting the adaptive patterning of melanocytes within the hair follicle. The study reveals two novel signaling mechanisms that shape melanocyte adaptive patterning and highlight the hair follicle as a regulatory hub for melanocyte physiological behaviors. These findings may inspire new clinical strategies for preventing hair greying.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.