ArticleActa psychiatrica Scandinavica2026
Relationships of Cognitive Function With Subsequent Device-Measured Physical Activity and Sedentary Time in Healthy Individuals and Those With Bipolar Disorder: Findings From the UK Biobank.
Article in Acta psychiatrica Scandinavica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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Who cites it
3 citing papers in PubMed.
- Sedentary Behavior and Physical Activity in Individuals With Bipolar Disorder: An Evidence Synthesis and Position Statement From the ISBD Nutrition and Exercise Task Force (NExT).Bipolar disorders · 2026Review
- Objective sleep parameters and cognitive performance in euthymic bipolar disorder: a cross-sectional 21-day actigraphy study.International journal of bipolar disorders · 2026Article
- Relationships of Cognitive Function With Subsequent Device-Measured Physical Activity and Sedentary Time in Healthy Individuals and Those With Bipolar Disorder: Findings From the UK Biobank.Acta psychiatrica Scandinavica · 2026Article
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Authors and funding
9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundIn bipolar disorder (BD), physical inactivity and sedentary behaviour are prevalent and have been linked to BD's cognitive symptoms, although the directionality of these links is not clear. This proof-of-concept study examined whether cognitive function during mid- and later-life was prospectively related to physical activity and sedentary time, and whether the association differed in presence or extent between those with BD and healthy controls.
methodsRelevant UK Biobank data were available for 646 BD participants and 18,041 psychiatrically healthy controls, aged 40-69 years at baseline. Cognition was assessed during a baseline assessment, and wrist-worn accelerometry data were collected at a follow-up assessment 2.8-6.6 years later. Regression analyses examined prospective relationships of global cognition, diagnostic group, and their interaction, with physical activity (total, light, and moderate to vigorous) and sedentary time.
resultsBaseline cognitive function was inversely associated with light physical activity (coeff. = -5.64, 95% CI: -6.30 to -4.98) and positively associated with sedentary time (coeff. = 5.17, 95% CI: 4.48-5.86) and moderate-to-vigorous physical activity (coeff. = 0.48, 95% CI: 0.28-0.68) at follow-up. Observed effect sizes were small but significant. In general, associations were not moderated by age or diagnostic group.
conclusionsThe current study provides preliminary evidence that cognitive function may influence subsequent physical activity and sedentary time similarly in those with BD and healthy controls; however, further research is needed to confirm and further explore this findings.
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