Evidence map›Paper›PMID 40611379›Full record

ArticleTransplantation2025

Pregnancy Outcomes Using Assisted Reproductive Technology in Kidney Transplant Recipients.

Silvi Shah, Brenna Rachwal, Prema Vyas, Pragati Basera, Swati Rao, Nisha Sheshashayee, Anthony C Leonard, Prasoon Verma, Jonathan Konel, Serban Constantinescu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Silvi ShahDivision of Nephrology and Hypertension, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH.
Brenna RachwalDivision of Nephrology and Hypertension, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH.
Prema VyasBurnett School of Medicine at Texas Christian University, Fort Worth, TX.
Pragati BaseraDivision of Nephrology and Hypertension, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH.
Swati RaoDivision of Nephrology, Department of Internal Medicine, University of Virginia, Charlottesville, VA.
Nisha SheshashayeeDivision of Nephrology and Hypertension, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH.
Anthony C LeonardDivision of Nephrology and Hypertension, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH.
Prasoon VermaDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH.
Jonathan KonelDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, MD.
Serban ConstantinescuTransplantation Pregnancy Registry International, Gift of Life Institute, Philadelphia, PA.
Michael MoritzTransplantation Pregnancy Registry International, Gift of Life Institute, Philadelphia, PA.
Shilpanjali JesudasonCentral Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, University of Adelaide, Adelaide, SA, Australia.
Lisa A CosciaTransplantation Pregnancy Registry International, Gift of Life Institute, Philadelphia, PA.

Funding

Sex Disparities in Cardiovascular Disease and Optimal Coronary Revascularization in Dialysis PatientsK23HL151816 · NHLBI · UNIVERSITY OF CINCINNATI · PI SHAH, SILVI · 2021 to 2025
$1.0M
NHLBI NIH HHS K23 HL151816
6 · The paper itself

Abstract

backgroundInfertility is common among those with kidney transplants, and pregnancy is associated with a high risk of adverse maternal and fetal outcomes. Little is known about the outcomes of pregnancy with assisted reproductive technology (ART) in women with kidney transplants.

methodsThis retrospective cohort study used data from the Transplant Pregnancy Registry International. Eligible participants were recipients of a kidney transplant between March 1968 and July 2022 who were aged 14 y or older at conception. Logistic regression analyses (adjusted for age at conception and race) were constructed to compare pregnancy outcomes with ART versus natural conception.

resultsThere were 130 pregnancies using ART in 77 kidney transplant recipients. ART pregnancies, as compared with natural conception pregnancies, were associated with a higher adjusted likelihood of hypertension during pregnancy (odds ratio [OR], 1.57; 95% confidence interval [CI], 1.06-2.32), higher adjusted likelihood of cesarean delivery (OR, 1.60; 95% CI, 1.02-2.51), and higher adjusted risk of preterm births <37 wk (OR, 2.07; 95% CI, 1.35-3.18). Pregnancies with ART, as compared with natural conception, had a lower median birth weight (2551 versus 2722.0 g), a lower median gestational age (36.0 versus 37.0 wk), and a higher proportion of neonatal deaths (4.4% versus 0.8%). No differences were observed in the adjusted likelihood of preeclampsia, gestational diabetes, miscarriages, live births, low birth weights, birth defects, or 2-y graft loss between ART and natural conception pregnancies.

conclusionsART pregnancies are associated with a higher risk of preterm births, hypertension during pregnancy, and cesarean delivery compared with naturally conceived pregnancies. The likelihood of live births and 2-y graft loss did not differ.

Indexed as

Kidney TransplantationPregnancy ComplicationsPregnancy OutcomeReproductive Techniques, AssistedAdultFemaleHumansInfant, NewbornLive BirthPregnancyRegistriesRetrospective StudiesRisk FactorsTransplant RecipientsYoung Adult

Identifiers

PMID40611379
PMCPMC12233136

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.