ArticleVeterinary research2025
A novel pilus-associated gene cluster is implicated in Streptococcus agalactiae virulence.
Article in Veterinary research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Clinically relevant genomic and phenotypic differences in virulence, antimicrobial resistance, and biofilm-associated tolerance between Streptococcus suis lineages ST1 and ST123.Veterinary research · 2026Article
- Kurarinone and sophoraflavanone G fromFrontiers in microbiology · 2026Article
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Authors and funding
7 authors.
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Abstract
Streptococcus agalactiae (S. agalactiae), also known as Group B Streptococcus (GBS), is an important zoonotic pathogen. It is an important pathogen that causes bovine mastitis and can also lead to severe infections in newborns, pregnant women, and individuals with a weakened immune system. Adhesion to host cells is the first critical step in S. agalactiae infection, making the identification of key adhesion-related genes essential for understanding the pathogenic mechanisms of GBS. In this study, we used the Tn transposon system to construct a mutant library of S. agalactiae A909 and employed the mouse mammary epithelial cell line EPH4-Ev as a model to screen and validate adhesion-related genes. Our results revealed a gene cluster containing BP, AP1, and SrtC. While these genes did not affect the basic biological characteristics of the bacteria, they significantly influenced the adhesion rate to cells and the virulence of A909 in mice. Further transcriptomic analysis revealed that the Tnfsf15 gene plays a critical role in the regulation of A909 strain pathogenicity mediated by the BP, AP1, and SrtC gene clusters during host infection.
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