Evidence map›Paper›PMID 40611326›Full record

ArticleJournal of health, population, and nutrition2025

Vitamin D status and risk for breast cancer in Kenya.

Ronald Wasike, Victor Mobegi, Esther Maina, Francis Makokha, Robert Armstrong, Annastacia Mbithi

Abstract read
In one paragraph

Article in Journal of health, population, and nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ronald WasikeDepartment of Surgery, Aga Khan University Hospital, Nairobi, Kenya.
Victor MobegiDepartment of Biochemistry, University of Nairobi, Nairobi, Kenya.
Esther MainaDepartment of Biochemistry, University of Nairobi, Nairobi, Kenya.
Francis MakokhaDepartment of Research, Mount Kenya University, Nairobi, Kenya.
Robert ArmstrongDepartment of Pediatrics, Aga Khan University Hospital, Nairobi, Kenya.
Annastacia MbithiDepartment of Internal Medicine, Aga Khan University Hospital, Aga Khan University, Nairobi, Kenya. mbithi111@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVitamin D plays a critical role in bone metabolism, calcium regulation, and various cellular processes, including those linked to cancer. The biologically active form, 1,25-dihydroxyvitamin D [1,25(OH)2D], works through the Vitamin D Receptor (VDR). Polymorphisms in VDR and related genes have been associated with cancer risk, including breast cancer. This case-control study aimed to investigate the relationship between serum vitamin D levels and breast cancer among Kenyan women.

methodsSerum 25-hydroxyvitamin D [25(OH)D] levels were measured in 112 breast cancer patients and 106 controls using electrochemiluminescence.

resultsResults indicated that 81.2% of participants had deficient or insufficient vitamin D levels, with controls showing slightly higher sufficient levels compared to cases. Although previous studies suggested an association between higher vitamin D levels and reduced breast cancer risk, our findings revealed no significant link between vitamin D levels and various demographic factors, including BMI.

conclusionThe study underscores the need for public awareness about vitamin D supplementation and further research to clarify the role of vitamin D in breast cancer development, particularly in populations with widespread vitamin D deficiency.

Indexed as

Breast NeoplasmsVitamin DVitamin D DeficiencyAdultAgedCase-Control StudiesFemaleHumansKenyaMiddle AgedReceptors, CalcitriolRisk Factors25-hydroxyvitamin DReceptors, CalcitriolVitamin DBreast cancerVitamin D

Identifiers

PMID40611326
PMCPMC12224571

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.