ArticleResearch involvement and engagement2025
Patient and public involvement in randomised controlled trial design and implementation: a process evaluation of the linking you to support and advice (LYSA) trial.
Article in Research involvement and engagement, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05035173 (Women's Cancer Survivorship), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Women's Cancer Survivorship: The LYSA (Linking You to Support and Advice) Trial
Who cites it
2 citing papers in PubMed.
- A complex survivorship intervention utilizing electronic patient-reported outcomes in breast and gynecologic Cancer: the linking you to support and advice [LYSA] trial.Breast (Edinburgh, Scotland) · 2026Trial
- Involving a black woman patient and public involvement group in maternal health methodology research: learning from the PROMISE Study.Research involvement and engagement · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe implementation of Patient and Public Involvement (PPI) in randomised controlled clinical trials (RCT) is crucial for improving the relevance and quality of research. PPI entails active engagement of patients and the public in various stages of the research process. The processes for effectively implementing PPI in RCTs remain underexplored and heterogeneous.
methodsAn explorative single case study of the Linking You to Support and Advice (LYSA) randomised controlled trial, NCT05035173, aims to evaluate the processes of implementation of PPI through different stages of the research cycle.
resultsThe development and review of the grant application resulted in a more patient focused study development. Furthermore, the review of surveys, questionnaires and patient facing study materials led to amendments mainly referring to the language used. PPI contributors helped to co-design the symptom management resources in partnership with the project team. Evaluation of the ePRO collection tool did not result in any further amendments. PPI contributors participated in the development of the study’s acronym and focus group discussion. As a direct result of PPI input further work and research was done in the area of metastatic breast cancer. PPI contributors participated in social media work, review and co-authorship of this paper.
conclusionsImplementation of PPI through different stages of RCT’s is effective. It highlighted the importance of PPI in improving the relevance and quality of research. While PPI offers numerous benefits, its implementation is not without challenges. Barriers such as resource and time constraints, and varying levels of stakeholder engagement pose a challenge to effective PPI integration.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.