Evidence map›Paper›PMID 40611289›Full record

ArticleBMC chemistry2025

Green HPLC strategy for quantification of carvedilol and hydrochlorothiazide in cardiac medications with in-vitro dissolution kinetics and impurity profiling.

Mona Nabil, Dina A Ahmed, Samah S Abbas, Hayam M Lotfy, Hoda M Marzouk

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mona NabilFaculty of Pharmacy, Cairo University, El-Kasr El-Aini Street, Cairo, 11562, Egypt.
Dina A AhmedPharmaceutical Chemistry Department, Faculty of Pharmacy, Future University in Egypt, Cairo, 11835, Egypt.
Samah S AbbasPharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, El-Kasr El-Aini Street, Cairo, 11562, Egypt.
Hayam M LotfyPharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, El-Kasr El-Aini Street, Cairo, 11562, Egypt.
Hoda M MarzoukPharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, El-Kasr El-Aini Street, Cairo, 11562, Egypt. hodaallah.marzouk@pharma.cu.edu.eg.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The introduction of new pharmaceutical formulations necessitates the development of a trustworthy analytical approach capable of quantifying active ingredients in various quality control procedures. A fixed dosage combination of carvedilol (CAR) and hydrochlorothiazide (HCT) has been introduced to treat hypertension with potential recommendation for diabetic patients. Ahigh-performance liquid chromatographic methodology, designed to be ecologically sustainable while maintaining high precision and accuracy, was established. This approach can simultaneously determine both drugs in their pure forms, and dosage form, along with separation and quantification of potential hydrochlorothiazide related impurities; salamide (DSA) and chlorothiazide (CT). Successful separation was performed using YMC

Indexed as

BluenessCarbon footprintCardiac pharmaceutical formulationsCarvedilolClick analytical chemistryDissolution testingGreenness profileHydrochlorothiazideImpurity profilingWhiteness assessment.

Identifiers

PMID40611289
PMCPMC12224793

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.