Behavioral phenotyping identifies autism-like repetitive stereotypies in a Tsc2 haploinsufficient rat model.

Antonia Ramme, Mirjam Zachow, Bettina Habelt, Iveta Vojtechova, Tomas Petrasek, Robert Waltereit, Nadine Bernhardt

Abstract read

In one paragraph

Article in Behavioral and brain functions : BBF, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Antonia RammeDepartment of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.ORCID http://orcid.org/0009-0004-8215-8692

Mirjam ZachowDepartment of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.

Bettina HabeltDepartment of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.ORCID http://orcid.org/0000-0001-8964-9698

Iveta VojtechovaNational Institute of Mental Health, Klecany, Czechia.

Tomas PetrasekNational Institute of Mental Health, Klecany, Czechia.ORCID http://orcid.org/0000-0002-3793-8364

Robert WaltereitDepartment of Child and Adolescent Psychiatry, University Medical Center, Göttingen, Germany.ORCID http://orcid.org/0000-0002-5338-2765

Nadine BernhardtDepartment of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. nadine.bernhardt@uniklinikum-dresden.de.ORCID http://orcid.org/0000-0002-3188-8431

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Besides deficits in social communication and interaction, repetitive behavior patterns are core manifestations of autism spectrum disorder (ASD). Phenotypes are heterogeneous and can range from simple lower-order motor stereotypies to more complex higher-order cognitive inflexibility and fixated interests. Due to ASD's multifaceted etiology, animal models are often generated from monogenic diseases associated with ASD, such as Tuberous Sclerosis Complex (TSC), and are expected to copy behavioral core deficits to increase the model´s translational value for ASD disease research and novel treatment development. The global haploinsufficient Tsc2

Indexed as

Autism Spectrum DisorderAutistic DisorderStereotyped BehaviorTuberous Sclerosis Complex 2 ProteinAnimalsBehavior, AnimalBrainDisease Models, AnimalDopamineGroomingHaploinsufficiencyMalePhenotypeRatsRats, TransgenicSocial BehaviorDopamineTsc2 protein, ratTuberous Sclerosis Complex 2 ProteinAutism spectrum disorderEker ratRepetitive behaviorTuberous sclerosis complex

Identifiers

PMID40611277

DOI10.1186/s12993-025-00284-z

PMCPMC12225118

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.