ArticleJournal of experimental & clinical cancer research : CR2025
Phosphorylation of KIAA1429 promotes oxaliplatin resistance through activating the FZD7-Wnt signaling in BRAF
Article in Journal of experimental & clinical cancer research : CR, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- KIAA1429 Stabilizes FAM84B mRNA to Enhance Colorectal Cancer Tumorigenesis via Wnt/β-Catenin Pathway.Biochemical genetics · 2026Article
- LINC00888 Promotes Gastric Cancer Growth and Metastasis by Sponging miR-145-5p to Regulate FZD7 Expression.Combinatorial chemistry & high throughput screening · 2026Article
- Nuclear-Cytoplasmic Axis in Cancer: From Protein Mislocalization to Anticancer Drug Resistance.Oncology research · 2026Review
- DNA, RNA, and histone methylation regulation enzymes and their crosstalk in colorectal carcinogenesis and progression: a review of molecular mechanisms, clinical implications, and future perspectives.Cellular & molecular biology letters · 2025Review
- KIAA1429 in non-small cell lung cancer: bridging m6A epigenetics to therapeutic innovation.Frontiers in surgery · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
backgroundThe current standard therapeutic approach for colorectal cancer (CRC) is surgical operation and oxaliplatin (OXA)-based neoadjuvant chemotherapy. However, the acquisition of oxaliplatin resistance leads to an unfavorable prognosis in CRC. Therefore, there is an urgent need to elucidate the underlying mechanisms of oxaliplatin resistance.
methodsRNA-sequencing (RNA-seq) analysis of OXA-resistant CRC cell line was used to identify the driver of OXA resistance. Function of KIAA1429 in OXA-resistance was validated by in vivo and in vitro experiments. The underlying mechanism was investigated by Immunoprecipitation-Mass Spectrometry (IP-MS), Co-Immunoprecipitation (Co-IP), Immunofluorescence (IF), RNA immunoprecipitation (RIP) and RNA-seq.
resultsKIAA1429 is significantly upregulated in oxaliplatin-resistant cell lines. However, we found that the expression level of KIAA1429 is not associated with the efficacy of neoadjuvant chemotherapy in colorectal cancer, indicating that the function of KIAA1429 is not solely determined by its expression level. We discovered that KIAA1429 exhibits differential nuclear and cytoplasmic distribution in colorectal cancer samples and that high cytoplasmic expression of KIAA1429 is associated with poor response to chemotherapy. Further investigation revealed that the nuclear-cytoplasmic distribution of KIAA1429 is regulated by BRAF-mediated phosphorylation. In vitro and in vivo experiments indicated that BRAF-mediated phosphorylation of KIAA1429 promotes oxaliplatin resistance by facilitating its aggregation in the cytoplasm. Mechanistically, we found that cytoplasmic KIAA1429 promotes WNT pathway activation by binding and stabilizing FZD7, thereby further enhancing cancer stemness and oxaliplatin resistance.
conclusionsThis study elucidates the unique role of KIAA1429 phosphorylation in regulating its nuclear localization and function, offering novel insights into the mechanisms underlying OXA-resistance in CRC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.