Observational studyCritical care (London, England)2025
Respiratory effort monitoring: a novel, bedside, non-invasive, real-time method.
Observational study in Critical care (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Lung- and diaphragm-protective mechanical ventilation in acute respiratory distress syndrome.Intensive care medicine · 2026Review
- Continuous and noninvasive respiratory effort monitoring: a narrative review of emerging techniques.Journal of intensive care · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMechanical ventilation is essential for treating respiratory failure. However, ventilator over-assistance can lead to ventilator-induced diaphragm dysfunction (VIDD), and insufficient assistance can necessitate excessive effort, which leads to high stress and damage diaphragm function. Current methods monitoring respiratory effort face clinical implementation challenges due to invasiveness and complexity. This study introduces and validates a novel non-invasive real-time respiratory muscle pressure (N-Pmus) monitoring method.
methods(1) The bench study involved developing a non-invasive, real-time respiratory muscle pressure monitoring algorithm (N-Pmus) based on the equation of motion of the respiratory system and validated with efforts generated by the ASL simulator (ASL5000-Pmus) across 270 clinical scenarios. (2) A clinical validation was performed through a prospective observational study (n = 23), comparing N-Pmus with the Pmus derived from simultaneously monitored esophageal pressure (Pmus
results(1) The bench study demonstrated that N-Pmus correlated well with ASL5000-Pmus, with marginal R²=0.993 and conditional R²=0.997. The bias was - 0.23 cmH₂O, with limits of agreement ranging from - 1.51 to 1.04 cmH₂O. (2) The clinical validation revealed strong N-Pmus/Pmus CLINICAL TRIAL NUMBER: Retrospectively registered with https://www.chictr.org.cn/ . REGISTRATION NUMBER: ChiCTR2300076940, registered 24 October 2023.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.