ArticleBMC chemistry2025
Eco-friendly QbD-optimized chromatographic method for simultaneous analysis of metronidazole and nicotinamide with applications in permeation, stability, and sustainability evaluation.
Article in BMC chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Use of Benzene-Free Carbomer 980 in the Formulation of Metronidazole Gel 0.75% and Demonstration of Equivalence with Carbomer 940.AAPS PharmSciTech · 2026Article
- Novel green UPLC method with life cycle assessment for determination of favipiravir and molnupiravir drugs and environmental water samples.Scientific reports · 2026Article
- Green analytical evaluation of anticancer drug analysis: A multi-tool assessment of HPLC and LC-MS methods.Scientific reports · 2026Article
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Authors and funding
8 authors.
Funding
Abstract
Metronidazole (MTZ) and nicotinamide (NCT) are co-formulated in Anaero® gel to treat skin conditions like acne and rosacea through combined antimicrobial and anti-inflammatory effects. This study presents the first validated in vitro permeation test (IVPT) method using Franz cells to assess the gel's drug release profile. Chromatographic separations were conducted with an RP-HPLC-photodiode array (PDA) system equipped with an ODS column using gradient elution of ethanol and phosphate buffer (10 mM, pH 3.5) at a flow rate of 1.0 mL/min. pre-optimized conditions were determined using a two-level full factorial design (2
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