Evidence map›Paper›PMID 40611210›Full record

ArticleBMC veterinary research2025

Serological and molecular survey of hepatitis E virus in pets in shaanxi, China.

Yiyang Chen, Huanqing Lin, Shenhao Xu, Longzhi Nie, Yujia Tang, Xinru Li, DanBa Zhaxi, Chengwei Zhang, Qin Zhao, En-Min Zhou and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC veterinary research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yiyang Chen *Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China.
Huanqing Lin *Kongtong Animal Disease Prevention and Control Center, Pingliang, Gansu, China.
Shenhao XuDepartment of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China.
Longzhi NieDepartment of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China.
Yujia TangDepartment of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China.
Xinru LiDepartment of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China.
DanBa ZhaxiGeneral Station of Animal Husbandry and Veterinary Technology Promotion, Naqu, Tibet, China.
Chengwei ZhangDepartment of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China.
Qin ZhaoDepartment of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China.
En-Min ZhouDepartment of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China.
Baoyuan LiuDepartment of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China. liubaoyuan0412@nwafu.edu.cn.

Funding

Kongtong Science and Technology Project of Pingliang PL-KT-2023A-005Natural Science Foundation of Shaanxi province 2024JC-YBMS-176
6 · The paper itself

Abstract

backgroundHepatitis E virus (HEV) is a zoonotic pathogen, and its infection is widespread in China. However, few studies were carried out on pets, especially in western China. Therefore, this study aimed to characterize the prevalence of HEV infection in pet dogs, cats, and rabbits. Serum samples from 177 pet dogs, 98 pet cats, and 56 pet rabbits were collected from a pet hospital located in Xi'an city of Shaanxi province, western China, to detect anti-HEV antibodies and HEV RNA.

resultsThe positivity rates of HEV IgG were 18.08% (32/177), 16.33% (16/98), and 10.71% (6/56) in pet dogs, cats, and rabbits, respectively. In addition, higher OD values of the anti-HEV IgM antibody were chosen for HEV detection, and the HEV RNA positivity rates were 0% (0/177), 0% (0/98), and 8.93% (5/56). Meanwhile, two different partial HEV ORF1 genes were obtained from 5 positive pet rabbit samples. These sequences shared 88.2% identity with each other and 48.6-98.2% identity with other HEVs. Phylogenetic analysis revealed that CN-SX-R1 and CN-SX-R2 (GenBank Nos. PP982770 and PP982771) detected in this study were closely related to genotype 3 HEV strains and belonged to rabbit HEVs.

conclusionsThese results showed that HEV was prevalent in pet dogs, cats, and rabbits in Shaanxi, suggesting that necessary measures must be taken to prevent and control HEV infection in these species.

Indexed as

Cat DiseasesDog DiseasesHepatitis EHepatitis E virusAnimalsCatsChinaDogsPetsPhylogenyPrevalenceRabbitsRNA, ViralSeroepidemiologic StudiesRNA, ViralHepatitis E virusPetsPrevalenceZoonotic

Identifiers

PMID40611210
PMCPMC12225384

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.