Evidence map›Paper›PMID 40611205›Full record

ArticleJournal of experimental & clinical cancer research : CR2025

The non-metabolic function of 6PGD coordinates CCNA2 and HMGA2 expression to drive colorectal cancer progression and drug response.

Mingming Sun, Qi Yan, Xinru Zhai, Xintong Dai, Chenxin Yang, Huifang Zhao, Sizhen Lai, Jiyan Wang, Lian Li, Zhen Li and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of experimental & clinical cancer research : CR, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Mingming Sun *State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, 300350, China.
Qi Yan *State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, 300350, China.
Xinru Zhai *State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, 300350, China.
Xintong DaiState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, 300350, China.
Chenxin YangSchool of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Huifang ZhaoSchool of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Sizhen LaiSchool of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Jiyan WangState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, 300350, China.
Lian LiState Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin, 300071, China.
Zhen LiKingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, 510180, China.
Yanping LiDepartment of Pathology, Institute of Precision Medicine, Jining Medical University, Jining, 272067, China.
Taoyuan WangCardiothoracic Surgery Department, Characteristic Medical Center of the Chinese People's Armed Police Force, Tianjin, 300162, China.
Tao HeDepartment of Pathology, Characteristic Medical Center of The Chinese People's Armed Police Force, Tianjin, 300162, China.
Jun XueDepartment of General Surgery, The First Affiliated Hospital of Hebei North University, Zhangjiakou, 075000, China.
Zhenghu JiaThe First Affiliated Hospital, Biomedical Translational Research Institute, Guangdong Province Key Laboratory of Molecular Immunology and Antibody Engineering, Jinan University, Guangzhou, 510632, China. jiazhenghu86@163.com.
Chunze ZhangDepartment of Colorectal Surgery, Tianjin Union Medical Center, Nankai University, Tianjin, 300121, China. chunze.zhang@nankai.edu.cn.
Shuai ZhangSchool of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China. shuaizhang@tjutcm.edu.cn.
Changliang ShanState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, 300350, China. changliangshan@nankai.edu.cn.

Funding

Basic and Applied Basic Research Foundation of Guangdong Province 2022A151511110China Postdoctoral Science Foundation 2023M741829 and 2023M741830Guangzhou Science and Technology Plan Project SL2022A04J00697National Natural Science Foundation of China 82373906 and 2273963the Youth Innovation Talent Project of Ordinary university in Guangdong Province 2022KQNCX061
6 · The paper itself

Abstract

Emerging evidence demonstrates that the metabolic and non-metabolic functions of metabolic enzymes play a key role in tumorigenesis and progression. 6-phosphogluconate dehydrogenase (6PGD) is a key metabolic enzyme in the pentose phosphate pathway (PPP), which displays aberrant expressions and functions in cancer. However, whether 6PGD serves non-metabolic functions in regulating cancer progression and drug response has not been reported. Here, we found that highly expressed 6PGD contributes to colorectal cancer (CRC) tumor growth and tumor metastasis. Mechanistically, 6PGD binds to ALKBH5 and inhibits its activity through the non-metabolic activity of 6PGD; this increases m

Indexed as

Colorectal NeoplasmsHMGA2 ProteinAnimalsCell Line, TumorCell ProliferationDisease ProgressionGene Expression Regulation, NeoplasticHumansMiceMice, NudeHMGA2 ProteinHMGA2 protein, human6-phosphogluconate dehydrogenase (6PGD)Colorectal cancer (CRC)MetastasisNon-metabolic activityProliferation

Identifiers

PMID40611205
PMCPMC12224427

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.