ArticleAnnals of general psychiatry2025
Abnormal static and dynamic regional homogeneity in adolescent major depressive disorder with somatic symptoms: a resting-state fMRI study.
Article in Annals of general psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Knowledge Graph and Large Language Model-Based Analysis of fMRI Brain Functional Neuroimaging Research.Bioengineering (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
backgroundSomatic symptoms are common in adolescent major depressive disorder (MDD) and related to severity of depression and clinical outcomes. However, the neurological mechanism of somatic symptoms in adolescent MDD remains unknown. In this study, we aimed to explore the functional alterations of intrinsic brain local connectivity in adolescent MDD with somatic symptoms based on static and dynamic reginal homogeneity (ReHo).
methodsThis study included 50 first-episode, drug naïve adolescent MDD patients and 34 healthy controls (HCs) matched for age, gender and years of education. Patients were categorized into somatic depression (SD) group (n = 21) and non-somatic depression (NSD) group (n = 29) based on the presence of somatic symptoms or not. All participants underwent resting-state functional magnetic resonance imaging (rs-fMRI), and static and dynamic ReHo were calculated and compared among SD, NSD and HC groups. Correlation analysis was performed to evaluate the relationship between altered ReHo values and severity of clinical symptoms.
resultsAdolescent MDD patients with somatic symptoms showed higher total scores of the 17-items Hamilton Depression Scale (HAMD-17). Moreover, increased static ReHo in left inferior parietal gyrus (IPG), left superior parietal gyrus (SPG) and left triangular part of inferior frontal gyrus (IFGtriang) were observed in SD group compared with NSD group. The SD group also exhibited decreased dynamic ReHo in bilateral IPG, bilateral SPG, and left IFGtriang. Moreover, there were significant correlations between static and dynamic ReHo values in these abnormal brain regions and the weight factor scores of HAMD-17.
conclusionsOur findings suggested that there may be abnormal patterns of functional local connectivity in SPG, IPG and IFGtriang in adolescent MDD patients with somatic symptoms, enriching the knowledge of neurological mechanism concerning somatic symptoms in adolescent MDD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.