ArticleBMC oral health2025
Single-cell analysis of ecto-mesenchymal cells derived from the neural crest reveals the regulatory role of P75NTR in odontogenic and osteogenic differentiation.
Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe aim to this study was to explore the effect of p75NTR on the mineralization and development of maxillofacial processes. Moreover, we tried to elaborate the potential mechanism of p75NTR's effect on the odontogenic or osteogenic differentiation ability of neural crest cells (s).
methodsWe used gene p75NTR knockout (p75NTR
resultsWe found the deletion of p75NTR could impact the communications between different cell types, influence differentiation and suppress odontogenesis via regulation networks of cytokines that associating with migration, proliferation and differentiation. The volcano plot characterized the distribution of differentially expressed genes (DEGs) in the selection at threshold level. p75NTR deletion suppressed EMSCs migration, proliferation and odonto/osteogenic differentiation in vitro.
conclusionsThis study provides a comprehensive analysis of the cellular fate of EMSCs in the maxillofacial process. p75NTR plays a crucial role in initiating hard tissue development and regulates the odontogenic and osteogenic differentiation of EMSCs during embryonic development.
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