ArticleBMC oral health2025
Assessment of photobiomodulation effect on osteoblast-like MG-63 cell biological behavior: analyzing proliferation and migration in the absence or presence of nicotine.
Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Biomaterial strategies for precision regeneration of the tooth extraction socket: integrating site phenotype, pathological microenvironment, and healing sequence.Frontiers in bioengineering and biotechnology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimNicotine has adverse cellular and molecular effects on periodontal tissue and alveolar bone. Photobiomodulation therapy (PBMT) through cellular stimulation may be able to reverse the effects of nicotine on bone. This study examines the effect of Photobiomodulation therapy (PBMT) on the proliferation and migration of MG-63 osteoblast-like cells in the presence and absence of nicotine. MATERIALS AND
methodsThe cytotoxic effects of 3 mM concentration and the protective effects of 660 and 808 nm low-level lasers on the MG-63 cell line were investigated and compared. Cell survival and proliferation were evaluated by the MTT assay (660 nm: Continuous, 150 mW, 0.5 cm², 240 mW/cm², 16 s, 4 J/cm², 808 nm: Continuous, 250 mW, 0.5 cm², 400 mW/cm², 10 s, 4 J/cm²), and cell migration was assessed by scratch test (660 nm: Continuous, 150 mW, 3 cm², 50 mW/cm², 200 s, 4 J/cm², 808 nm: Continuous, 250 mW, 3 cm², 83.3 mW/cm², 114 s, 4 J/cm²).
resultsThe results of this study showed that 3 millimolar nicotine concentration has cytotoxic effects on the survival, proliferation, and migration of MG-63 cells (p < 0.05). Additionally, it was found that 660 nm and 808 nm low-level lasers alone or in combination could not increase survival and proliferation in MG-63 cells treated with nicotine (p < 0.05). However, the results demonstrated that PBMT with 660 and 808 nm lasers could increase cellular migration of MG-63 cells treated with nicotine (p < 0.05).
conclusionThe results of the current study clearly demonstrate that PBMT, particularly 808 and 660 nms low-level lasers, are effective in improving the migration and repair of MG-63 cells treated with nicotine. However, they could not reduce the negative effects of nicotine on the survival and proliferation of MG-63 cells. Further research is essential to investigate the effects of PBMT on bone tissue healing and regeneration in smokers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.