ArticleBMC pregnancy and childbirth2025
The value of first trimester inflammatory indices in predicting the development of preeclampsia in the third trimester.
Article in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- First-Trimester Zinc Supplementation Reduces Preeclampsia Incidence in Chronic Hypertensive Pregnancies: A Single-Center Retrospective Observational Study.Biological trace element research · 2026Observational
- Role of second-trimester hematological and biochemical indicators in predicting preeclampsia: a retrospective study.BMC pregnancy and childbirth · 2026Article
- Systemic Immune-Inflammation Index as a Predictive Biomarker for Pre-Eclampsia.Journal of clinical medicine · 2026Review
- First-trimester β-hCG, PAPP-A, and NLR in relation to preeclampsia and perinatal outcomes: A case-control study.Science progressArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to evaluate the predictive value of hematologic inflammatory markers measured during the first trimester for developing preeclampsia in the third trimester.
methodsThis retrospective study included 192 pregnant women diagnosed with preeclampsia and 159 healthy pregnant women who presented to the Obstetrics and Gynecology Clinic of Sİrnak State Hospital between March 2024 and March 2025. Demographic data, obstetric history, and laboratory results were retrospectively analyzed. Inflammatory markers derived from complete blood count parameters—including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), systemic immune-inflammation index (SII), systemic inflammatory response index (SIRI), and aggregate index of systemic inflammation (AISI)—were compared between the two groups.
resultsThe mean age in the preeclampsia group was significantly higher (p = 0.002), while gestational age at delivery and birth weight were significantly lower (p < 0.001). Levels of hemoglobin, hematocrit, white blood cell count, and inflammatory markers such as NLR, SII, SIRI, and AISI were significantly lower in the preeclampsia group (p < 0.05). Monocyte counts were also significantly lower (p < 0.05). No statistically significant differences were observed between the groups regarding PLR and LMR.
conclusionCertain hematological inflammatory markers measured in the first trimester may serve as potential biomarkers for predicting the development of preeclampsia. Incorporating these markers into routine prenatal follow-up could contribute to the early identification of high-risk pregnancies.
trial registrationThis study was not registered in a trial registry as it is a retrospective observational study involving analysis of previously collected data.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.