ArticleBMC public health2025
Knowledge, attitudes, and practices regarding preconception or early pregnancy single-gene genetic disease screening among reproductive-aged individuals.
Article in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Knowledge, Attitudes, Religiosity, and Reproductive Genetic Carrier Screening: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2026Article
- Article
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed to assess the knowledge, attitudes, and practices (KAP) regarding preconception or early pregnancy single-gene genetic disease screening among individuals in early pregnancy or preparing for pregnancy.
methodsA cross-sectional survey was conducted from April 1, 2024, to June 30, 2024, using a validated, self-designed questionnaire which was distributed online to collect data on participants' demographic information and KAP scores.
resultsA total of 562 valid questionnaires were obtained, with 397 (70.64%) female participants. The median (IQR) scores for knowledge, attitude, and practice were 17 (7, 29) (possible range: 0-42), 40 (35, 44) (possible range: 11-55), and 30 (19, 36) (possible range: 9-45), respectively. The mediation analysis based on path analysis model demonstrated that the number of children (β = 0.178, p = 0.005), screening experience (β = -0.288, p = 0.001), gender (β = -0.162, p = 0.016), and binge drinking (β = 0.150, p = 0.006) directly influenced knowledge. Additionally, knowledge (β = -0.224, p = 0.013), occupation (β = 0.119, p = 0.015), education (β = 0.181, p = 0.015), gender (β = 0.182, p = 0.004), and binge drinking (β = -0.158, p = 0.011) directly affected attitude. Practice was directly influenced by knowledge (β = -0.163, p = 0.007), attitude (β = 0.609, p = 0.009), number of premature births (β = 0.087, p = 0.006), and number of abortions (β = 0.114, p = 0.013). Gender (β = 0.036, p = 0.010) and binge drinking (β = -0.034, p = 0.005) indirectly affected attitude, while knowledge (β = -0.136, p = 0.011) indirectly influenced practice.
conclusionsIndividuals either in early pregnancy or preparing for pregnancy in our study population demonstrated variable levels of knowledge, generally positive attitudes, and moderate practices towards preconception and early pregnancy single-gene genetic disease screening. Targeted educational interventions should be implemented to enhance knowledge and improve screening practices, particularly focusing on groups with lower knowledge scores, such as those with less screening experience or specific demographic characteristics. CLINICAL TRIAL REGISTRY NUMBER: Not applicable.
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