Evidence map›Paper›PMID 40611033›Full record

SynthesisBMC surgery2025

Effect of dexamethasone on rebound pain and analgesic effects after upper limb surgery under brachial plexus block: a meta-analysis.

Chengyu Qian, Xiaojing Wei, Jixiao Zhang, Yutong Zhao, Shukai Li, Zhixue Wang

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chengyu QianDepartment of Anesthesiology, The Affiliated Hospital of Chengde Medical University, Chengde, 067000, China.
Xiaojing WeiDepartment of Anesthesiology, Chengde County Hospital of Traditional Chinese Medicine, Chengde, 067000, China.
Jixiao ZhangDepartment of Anesthesiology, The Affiliated Hospital of Chengde Medical University, Chengde, 067000, China.
Yutong ZhaoDepartment of Anesthesiology, The Affiliated Hospital of Chengde Medical University, Chengde, 067000, China.
Shukai LiDepartment of Anesthesiology, Beijing Luhe Hospital Affiliated with Capital Medical University, Beijing, 10000, China.
Zhixue WangDepartment of Anesthesiology, The Affiliated Hospital of Chengde Medical University, Chengde, 067000, China. propofol2012@cdmc.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo systematically evaluate the effect of dexamethasone on rebound pain after brachial plexus block upper limb surgery and its impact on analgesic optimization through the method of meta-analysis.

methodsRegistered in PROSPERO. Randomized controlled trials (RCTs) on the application of dexamethasone in upper limb fracture surgery under brachial plexus block were retrieved from the PubMed, Medline and Embase databases. RevMan 5.4 was used by two independent researchers to screen the literature gradually, evaluate its quality, extract the data, and finally merge the data.

resultsSeven studies involving 485 patients were included. The comprehensive results showed that dexamethasone could reduce the incidence of rebound pain (RR = 0.38, 95% CI 0.28-0.51, P < 0.00001, I

conclusionDexamethasone, as an adjuvant, maybe can reduce the incidence of postoperative rebound pain under brachial plexus block for upper extremity surgery, lower the VAS score at 12 h postoperatively, reduce the incidence of PONV, and prolong the first rescue time for postoperative analgesia, thereby optimizing its postoperative analgesic effect.

Indexed as

Brachial Plexus BlockDexamethasonePostoperative PainUpper ExtremityHumansPostoperative Nausea and VomitingRandomized Controlled Trials as TopicDexamethasoneBrachial plexus blockDexamethasoneMeta-analysisRebound painUpper limb surgery

Identifiers

PMID40611033
PMCPMC12232067

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.