Evidence map›Paper›PMID 40610989›Full record

ArticleBMC psychiatry2025

Dietary intake and five types of mental disorders: a bidirectional Mendelian randomization study.

Yichun Zhang, Mingzhu Zhang, Qihua Guan, Pengcheng Liu, Wangxin Zhang, Song Yang, Hualei Dong, Haifeng Hou

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PubMed Full text at PMC Publisher
In one paragraph

Article in BMC psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yichun Zhang *Jining Hospital of Xiyuan Hospital of CACMS, Jining, China.
Mingzhu Zhang *School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.
Qihua Guan *School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.
Pengcheng LiuDepartment of Epidemiology and Biostatistics and Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Wangxin ZhangDepartment of Medical Psychology, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, China.
Song Yang *Department of Endocrinology, The Affiliated Taian City Central Hospital of Qingdao University, 29 Longtan Road, Taian, 271000, China. yangsong2@qdu.edu.cn.
Hualei Dong *Department of Sanatorium, Shandong Provincial Taishan Hospital, 3 Tianwaicun Street, Taian, 271000, China. donghualei@163.com.
Haifeng HouSchool of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.

Funding

Natural Science Foundation of Shandong Province ZR202111250056
6 · The paper itself

Abstract

backgroundMental illness has been presenting serious public health concerns. Studies have linked mental disorders to poor dietary patterns. The study aimed to estimate the causal relationship between dietary macronutrient intake and mental disorders using a bidirectional two-sample Mendelian randomization (MR) analysis.

methodsThe causal relationships between dietary macronutrient intake (i.e., carbohydrate, fat, protein and sugar) and mental disorders (i.e., anxiety, bipolar disorder, depression, neuroticism and schizophrenia) were explored on the basis of UK Biobank and 5 datasets. Inverse-variance weighted (IVW) and weighted median (WM) methods were applied to calculate the potential causation between macronutrient and mental disorders. MR-Egger's intercept and MR-PRESSO approaches were used to verify the MR assumptions. Outcomes were reported as odds ratios (OR) and regression coefficients (β), which were adjusted by False Discovery Rate (FDR) corrections.

resultsForward MR analyses revealed that genetically predicted high-fat and high-protein intakes were related to an increased risk of anxiety [fat: OR = 3.103, 95% confidence interval (CI): 1.015 to 9.486, P

conclusionsOur findings demonstrated that although the effects of psychiatric diseases on diet patterns have been well understood, the potential impacts of dietary intake on mental disorders are needed to be highlighted. CLINICAL TRIAL NUMBER: Not applicable.

Indexed as

DietMendelian Randomization AnalysisMental DisordersAnxiety DisordersBipolar DisorderDietary CarbohydratesDietary FatsDietary ProteinsHumansSchizophreniaDietary CarbohydratesDietary FatsDietary ProteinsBidirectional causalityDietary intakeMacronutrientMendelian randomizationMental disorders

Identifiers

PMID40610989
PMCPMC12231975

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.