Evidence map›Paper›PMID 40610912›Full record

ArticleBMC pediatrics2025

Epidemiology of childhood constipation: a national study of Swedish children from 2006 to 2023.

Helena Kornfält Isberg, Kathy Falkenstein-Hagander, Cecilia Lenander, Mariette Derwig, Lars Hagander

Abstract read
In one paragraph

Article in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Helena Kornfält IsbergDepartment of Clinical Sciences, Family Medicine and Community Medicine, Lund University, Malmö, Sweden. helena.isberg@med.lu.se.
Kathy Falkenstein-HaganderUnit for Knowledge-Based Management, Department of Health Care Management, County of Scania, Sweden.
Cecilia LenanderDepartment of Clinical Sciences, Family Medicine and Community Medicine, Lund University, Malmö, Sweden.
Mariette DerwigUnit for Knowledge-Based Management, Department of Health Care Management, County of Scania, Sweden.
Lars HaganderPediatric Surgery, Department of Clinical Sciences Lund, Lund University, Skane University Hospital Lund, Lund, 22184, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChildhood constipation is increasingly common, yet its prevalence is uncertain. This study examines comprehensive national data for trends in medically treated childhood constipation over a period of 18 years.

methodsIncluded were all Swedish children, 0-14 years, 2006-2023, and all prescriptions for constipation, using the national Swedish Prescribed Drug register. The primary outcome was the number of unique patients prescribed, presented by age, gender, year, county, and ATC-code. Univariate and multivariable linear regression with ecological data were assessed for associations with age, gender, and year of prescription.

resultsThe study population increased from 1.54 to 1.84 million children 0-14 years, while constipation increased more than sixfold, from 1.2% in 2006 to 7.9% in 2023. Children 0-4 years were prescribed the most, with an increase from 1.6 to 9.5%. Female gender was associated with 7.5 higher prescription frequency per 1000 inhabitants when adjusted for age and year (4.6-10.5 95%CI, p < 0.001). In 2023, girls aged 0-4 years were prescribed 27% more than boys (106.5 vs. 83.7 per 1000), compared with 23% among the 5-9-year-olds (86.8 vs. 70.6 per 1000), and 18% among the 10-14-year-olds (45.0 vs. 38.1 per 1000).

conclusionsPrescription of constipation drugs to children has increased remarkably during the past 18 years. This study highlights an escalating public health challenge among children, with considerable associated costs for family and society.

Indexed as

ConstipationLaxativesAdolescentChildChild, PreschoolDrug PrescriptionsFemaleHumansInfantInfant, NewbornMalePrevalenceRegistriesSwedenLaxativesChildrenConstipationDrugsEpidemiologyLaxativeMacrogol

Identifiers

PMID40610912
PMCPMC12225474

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.