ArticleThe journal of headache and pain2025
Shared neural signatures of photophobia in migraine and post-traumatic headache: a task-based fMRI study.
Article in The journal of headache and pain, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- TRPV1‑mediated central sensitisation: Core mechanisms of migraine chronification and novel targeted therapeutic strategies (Review).International journal of molecular medicine · 2026Review
- Spectral Composition of Ambient White Light Modulates Photophobia and Headache Intensity During Migraine Attacks.Neurology and therapy · 2026Article
- The effects of physical exercise on inflammation-induced maladaptive neuroplasticity in post-traumatic headache.Neuroscience · 2026Review
- Shared and Specific Patterns of Brain Functional Network Abnormalities in Patients With Idiopathic Dystonia and Across Subtypes.CNS neuroscience & therapeutics · 2026Article
- Posterior insular cortex hyperactivation drives vestibular migraine and comorbid anxiety.The journal of headache and pain · 2026Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPersistent post-traumatic headache (PTH) and migraine frequently present with photic hypersensitivity that exacerbates headache symptoms. We sought to determine whether persistent PTH is associated with altered brain responses to visual stimuli and to explore shared neural mechanisms of photophobia with migraine.
methodsThis cross-sectional functional magnetic resonance imaging (fMRI) study included 80 adults with persistent PTH, 261 with migraine, and 143 healthy controls (HCs). All participants underwent visual stimulation using a flickering checkerboard during a 3T fMRI session. Blood oxygen level-dependent (BOLD) responses were examined using whole-brain and region-of-interest (ROI) analyses. All analyses were adjusted for age and sex.
resultsWhole-brain analysis revealed no significant BOLD differences across the full persistent PTH, migraine, and HC groups. However, participants with persistent PTH who experienced photophobia during the scan (n = 41) showed greater activation in the anterior and midcingulate cortex compared with HCs (P
conclusionsPhotophobia in persistent PTH is associated with greater activation in cortical regions implicated in pain processing. These patterns parallel those observed during migraine attacks, indicating shared neural mechanisms between the two headache disorders.
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