ArticleBMC plant biology2025
Joint analysis of transcriptome and metabolome on the accumulation mechanism of flavonoids in quinoa seedlings under flooding stress.
Article in BMC plant biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Transcriptome-Based Dissection of the Molecular Mechanisms Underlying Flooding Stress Responses of Eastern Cottonwood in the Floodplains of the Middle and Lower Reaches of the Yangtze River.Plants (Basel, Switzerland) · 2026Article
- Review
- Quinoa as a naturally stress-resistant crop: current status and future promises.Stress biology · 2026Review
- Identification and functional validation of hub genes responding to waterlogging stress during the filling period in quinoa (Chenopodium Quinoa Willd.).BMC plant biology · 2026Article
- Molecular basis of quinoa's resilience to abiotic stresses: implications for climate-adaptive crop breeding.Frontiers in plant science · 2026Review
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15 authors.
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Abstract
backgroundAs a nutrient rich pseudocereal crop, quinoa is severely restricted by waterlogging, which hinders the growth and development of quinoa seedlings. The accumulation mechanism of flavonoids in quinoa under abiotic stress has been reported, but there are few reports on the accumulation of flavonoids in quinoa seedlings under waterlogging.
methodsWe used one highly resistant and two sensitive lines as experimental materials, and combined metabolomic and transcriptomic associations as well as WGCNA to describe and analyze in detail the accumulation of flavonoids in quinoa seedlings under flooding stress in three quinoa lines.
resultsThe results showed that under flooding stress, the total flavonoid content in highly resistant materials was higher than that in sensitive materials. A total of 173 flavonoid metabolites were detected in all samples, mainly flavonoids and flavonols. Gene metabolite regulatory network analysis showed that a total of 22 genes regulated 11 enzymes and 13 metabolites that played key roles in response to flooding stress, among which CHS, F3H, and FLS genes showed strong and significant positive correlations with various flavonoid metabolites.Combined with WGCNA, five transcription factors (TFs) related to the synthes is of flavonoids under waterlogging were identified, including MYB and NF-YC, And these genes were validated by RT-qPCR, and the expression levels were consistent with RNA sequencing (RNA-seq) data, thus confirming the reliability of our data.
conclusionsThis study elucidated that quinoa significantly enhances the synthesis of flavonoids under flooding stress through the synergistic regulation of key genes such as CHS, F3H, FLS and the MYB and NF-YC transcription factors, providing an important theoretical basis and genetic resources for analyzing the mechanism of quinoa's flooding tolerance and cultivating varieties that are resistant to waterlogging.
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