Evidence map›Paper›PMID 40610837›Full record

ArticleDiscover oncology2025

Clinical value of the worst pattern of invasion in predicting extranodal extension in oral squamous cell carcinoma.

Mirai Higaki, Toshinori Ando, Fumitaka Obayashi, Nanako Ito, Suguru Hirota, Atsuko Hamada, Sachiko Yamasaki, Tomoaki Shintani, Koichi Koizumi, Souichi Yanamoto

Abstract read
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In one paragraph

Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mirai HigakiDivision of Dentistry, Department of Oral Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan. mirai-higaki@hiroshima-u.ac.jp.
Toshinori AndoCenter for Oral Clinical Examination, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan.
Fumitaka ObayashiDivision of Dentistry, Department of Oral Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan.
Nanako ItoDivision of Dentistry, Department of Oral Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan.
Suguru HirotaDivision of Dentistry, Department of Oral Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan.
Atsuko HamadaDivision of Dentistry, Department of Oral Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan.
Sachiko YamasakiDivision of Dentistry, Department of Oral Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan.
Tomoaki ShintaniCenter for Oral Clinical Examination, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan.
Koichi KoizumiDivision of Dentistry, Department of Oral Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan.
Souichi YanamotoDivision of Dentistry, Department of Oral Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveExtranodal extension (ENE) is one of the major influencing factors for the oncological outcomes in oral squamous cell carcinoma (OSCC). We aimed to elucidate the clinical features predictive of ENE in OSCC. MATERIALS AND

methodsWe conducted a retrospective analysis of patients with OSCC who underwent neck dissection (ND) with a confirmed pN + status. Cases in which the histopathological evaluation was compromised by preoperative chemotherapy or radiotherapy were excluded. Histopathological evaluation of extent of ENE category and grading of worst pattern of invasion (WPOI) was compared for available cases.

resultsFifty-nine patients met the inclusion criteria for the study. Of these, 32/59 (54.2%) were ENE-positive. A higher incidence of ENE was observed in cases where ND was performed at a separate time from the primary tumor resection (odds ratio [OR] = 11.0, 95% confidence interval [95%CI] 2.23-54.5, P = 0.003). Additionally, a higher grade of WPOI (WPOI 4 or 5) was significantly associated with ENE occurrence (OR = 4.53, 95%CI 1.19-20.50, P = 0.026). A positive correlation between the WPOI grade and ENE extent was also identified (ρ = 0.412, P <.001).

conclusionWe demonstrated an association between WPOI and ENE in patients with OSCC.

Indexed as

Extranodal extensionNeck dissectionOral squamous cell carcinomaWorst pattern of invasion

Identifiers

PMID40610837
PMCPMC12226440

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.