Evidence map›Paper›PMID 40610796›Full record

ArticleDigestive diseases and sciences2025

Predicting Esophageal Varices and Varices Needing Treatment in Compensated Advanced Chronic Liver Disease.

Ragesh B Thandassery, Nimy John, Fares A Mashal, Cody J Timmermann, Yash Shaw, Mauricio Garcia Saenz de Sicilia, Johnathan A Dranoff

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Digestive diseases and sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Ragesh B ThandasseryDivision of Gastroenterology and Hepatology, University of Arkansas for Medical Sciences, Little Rock, AR, USA. rthandassery@uams.edu.ORCID http://orcid.org/0000-0002-5357-4847
Nimy JohnDivision of Gastroenterology and Hepatology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Fares A MashalDivision of Gastroenterology and Hepatology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Cody J TimmermannDivision of Gastroenterology and Hepatology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Yash ShawDivision of Gastroenterology and Hepatology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Mauricio Garcia Saenz de SiciliaDivision of Gastroenterology and Hepatology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Johnathan A DranoffSection of Digestive Diseases, Department of Medicine, VA Connecticut Healthcare System, New Haven, CT, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeMany noninvasive scoring systems have been proposed to identify patients with compensated advanced chronic liver disease (cACLD). However, these scores have not been compared for their accuracy in predicting clinically significant portal hypertension (CSPH). We compared head-to-head the accuracy of recently described noninvasive scores for predicting CSPH (esophageal varices [EV] and varices needing treatment [VNT]) in patients with cACLD.

methodsWe compared the ability of Baveno VI criteria (BC), expanded BC (EBC), aspartate transaminase platelet count ratio index, MELD-Na, liver stiffness measurement, fibrosis (FIB)-4 score, CHESS-ALARM score, and FIB-5 score to predict the presence of EV and VNT in a cohort of patients with cACLD.

resultsBC and EBC correctly identified patients with EV, gastric varices (GV), and VNT. BC spared esophagogastroduodenoscopy (EGD) in 48% of patients, with 6.4% miss rate for EV; EBC spared EGD in 60% of patients, with 0% miss rate for VNT. The miss rates of EV resulting from BC were similar between groups with or without metabolic dysfunction-associated steatotic liver disease (MASLD) and between obese and nonobese MASLD groups. BC (p < 0.001), EBC (p < 0.001), CHESS-ALARM score (p < 0.001, cut off > 0.37), and FIB-5 score (p < 0.001, cut off > 0.75) independently predicted EV and VNT.

conclusionsBC and EBC could spare EGD in patients with cACLD, with low miss rates for EV, GV, and VNT. Their performance was similar for the MASLD and non-MASLD groups. CHESS-ALARM score and FIB-5 score are highly accurate for predicting CSPH (EV and VNT) in patients with cACLD.

Indexed as

Esophageal and Gastric VaricesHypertension, PortalAdultAgedChronic DiseaseEndoscopy, Digestive SystemFemaleHumansLiver CirrhosisMaleMiddle AgedPlatelet CountPredictive Value of TestsRetrospective StudiesSeverity of Illness IndexBaveno criteriaClinically significant portal hypertensionCompensated advanced chronic liver diseaseEsophageal varicesNoninvasive scoreVarices needing treatment

Identifiers

PMID40610796

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.