Evidence map›Paper›PMID 40610780›Full record

ArticleAnnals of biomedical engineering2025

Pulmonary Artery Shear Stress and Oscillatory Shear Index are Associated with Right Ventricular Remodeling in Repaired Tetralogy of Fallot.

Elizabeth W Thompson, Anindro Bhattacharya, Fengling Hu, Russell T Shinohara, Paris Perdikaris, Kevin K Whitehead, Elizabeth Goldmuntz, Mark A Fogel, Walter R Witschey

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of biomedical engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Elizabeth W ThompsonAdvanced Cardiovascular Imaging Lab, 11-160 Perelman Center for Advanced Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. elizabeth.thompson@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0002-1094-8861
Anindro BhattacharyaDepartment of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, United States.ORCID http://orcid.org/0009-0005-0194-151X
Fengling HuDepartment of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-1081-5038
Russell T ShinoharaDepartment of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-8627-8203
Paris PerdikarisDepartment of Mechanical Engineering and Applied Mechanics, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-2816-3229
Kevin K WhiteheadDivision of Cardiology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-7343-7949
Elizabeth GoldmuntzDivision of Cardiology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-2936-4396
Mark A FogelDivision of Cardiology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-7490-3702
Walter R WitscheyDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-1669-2120

Funding

High Spatial and Temporal Resolution MRI Mapping of Oxygen Consumption in HumansP41EB029460 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI Ravinder Reddy · 2021 to 2026
$7.6M
Acute Imposition of Fontan Physiology in The Single Ventricle Patient: Effects on Fibrosis, Function and Drug InterventionR01HL149139 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI FOGEL, MARK A · 2020 to 2023
$3.0M
Non-invasive imaging of reactive oxygen species in reperfusion injury myocardial infarctionR01HL169378 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI PACO E. BRAVO, Walter R.T. Witschey · 2023 to 2026
$3.0M
LONGITUDINAL ASSOCIATION OF POST-INFARCT LIPOMATOUS METAPLASIA AND MALIGNANT ARRHYTHMIAR01HL171709 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Saman Nazarian, Walter R.T. Witschey · 2024 to 2026
$2.2M
Right Ventricular Remodeling in Tetralogy of FallotF30HL162429 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Elizabeth Walker Thompson · 2022 to 2026
$247k
Children's Hospital of Philadelphia Cardiac Center Innovation AwardNHLBI NIH HHS F30 HL162429NHLBI NIH HHS F30HL162429NHLBI NIH HHS R01 HL149139NHLBI NIH HHS R01HL149139NHLBI NIH HHS R01 HL169378NHLBI NIH HHS R01HL169378NHLBI NIH HHS R01 HL171709NHLBI NIH HHS R01HL171709NIBIB NIH HHS P41 EB029460NIBIB NIH HHS P41EB029460
6 · The paper itself

Abstract

purposeRight ventricular (RV) remodeling in repaired tetralogy of Fallot (rToF) is a multifactorial process that may be affected by downstream hemodynamics. We therefore sought to characterize hemodynamics in the pulmonary arteries (PAs) of rToF patients using cardiovascular magnetic resonance (CMR)-derived computational fluid dynamics (CFD) and to study these variables in association with RV measurements at follow-up.

methodsWe selected patients with two CMRs who had magnetic resonance angiography (MRA) performed at baseline. The PA was segmented from the main PA (MPA) through the first bifurcation of the left PA (LPA) and right PA (RPA). Both steady and pulsatile simulations were performed. For each vessel, we calculated curvature, tortuosity, and both average (avg) and peak steady WSS (WSS

results22 patients met the inclusion criteria. Several focal hemodynamic metrics in the main and branch PAs, including WSS

conclusionCFD-derived hemodynamic variables in the PAs of rToF patients are associated with both PVR and RV remodeling.

Indexed as

Models, CardiovascularPulmonary ArteryTetralogy of FallotVentricular RemodelingAdolescentAdultChildFemaleHemodynamicsHumansMagnetic Resonance AngiographyMaleStress, MechanicalCardiovascular magnetic resonance (CMR)Computational fluid dynamics (CFD)Pulmonary arteryRepaired tetralogy of Fallot (rToF)Right ventricular remodelingTetralogy of Fallot (ToF)

Identifiers

PMID40610780
PMCPMC12391157

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.