ArticleInternational journal of obesity (2005)2025
Dynapenic obesity associated with incidence and progression trajectory of cardiometabolic diseases: a prospective cohort study.
Article in International journal of obesity (2005), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Longitudinal cohort study on the dynamic changes of atherogenic index of plasma and the risk of cardiometabolic multimorbidity in middle - aged and elderly people.BMC cardiovascular disorders · 2026Article
- Longitudinal prevalence and correlates of dynapenic abdominal obesity among community-dwelling ageing adults in rural South Africa from 2015 to 2022.Scientific reports · 2026Article
- Dynapenic Abdominal Obesity and the Risk of Stroke in Postmenopausal Women.International journal of women's health · 2026Article
- Using Interpretable Machine Learning with SHAP to Assess Dynapenic Abdominal Obesity as a Stroke Risk Predictor: A Prospective Cohort Study.Vascular health and risk management · 2026Article
- Amino acid metabolic signatures of dynapenic obesity in older adults: a (principal component analysis) PCA-based sex-stratified analysis in the Bushehr elderly health program.Journal of diabetes and metabolic disorders · 2025Article
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11 authors.
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Abstract
backgroundThe impact of dynapenic obesity on the progression of cardiometabolic multimorbidity (CMM) remains poorly understood. This study aimed to explore the association between dynapenic obesity and cardiometabolic diseases (CMD) progression, as well as the mediating roles of C-reactive protein (CRP) and the atherogenic index of plasma (AIP).
methodsThe study included 446,862 UK Biobank participants. CMM was defined as the coexistence of two or three CMDs, including type 2 diabetes (T2DM), coronary heart disease (CHD) and stroke. Dynapenic obesity was classified into dynapenic general obesity and dynapenic abdominal obesity, assessed by handgrip strength (HGS), body mass index (BMI), and waist circumference (WC). A multi-state model was employed to evaluate the influence of dynapenic obesity on CMD progression. Counterfactual mediation analyses were conducted to investigate the mediating role of CRP and AIP.
resultsOver a median 13.67-years follow-up, 54,555 participants developed CMD, 5842 developed CMM, and 32,930 died. Compared with non-dynapenia and non-general obesity (ND/NGO), the HRs (95% CI) of first CMD (FCMD), CMM, and death for dynapenia and general obesity (D/GO) were 2.75 (2.61,2.90), 4.61 (4.05,5.24), and 1.68 (1.56,1.80), respectively. Similar results were observed for dynapenic abdominal obesity. Compared with ND/NGO, the proportions of CRP and AIP mediated associations of D/GO with FCMD risk were 19.58% (95% CI: 18.66%, 20.18%) and 18.99% (95% CI: 18.12%, 19.62%), respectively, which were lower than the proportions mediated in the associations of dynapenia and abdominal obesity (D/AO) with FCMD (CRP: 30.38% vs. 19.58%; AIP: 31.40% vs. 18.99%). Furthermore, CRP and AIP accounted for a greater proportion of the association between dynapenic obesity and CMM than FCMD.
conclusionThis study indicated that there are differential effects associated with dynapenic obesity during the longitudinal progression of CMD. CRP and AIP may play a partial role in mediating this association.
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