Evidence map›Paper›PMID 40610757›Full record

Trial reportInternational journal of obesity (2005)2025

The influence of physical activity intensity on bone mineral density and trabecular bone score in young adults with overweight and obesity.

Horacio Sanchez-Trigo, David Wing, Shadia J Mansour-Assi, Jeanne F Nichols, Britta A Larsen, Borja Sañudo, Natalie M Yarish, Sonia Jain, Job G Godino

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International journal of obesity (2005), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The association between theFrontiers in genetics · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Horacio Sanchez-TrigoPhysical Education and Sports Department, University of Seville, Seville, Spain. fstrigo@us.es.ORCID 0000-0002-1830-8236
David WingHerbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, CA, USA.
Shadia J Mansour-AssiHerbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, CA, USA.
Jeanne F NicholsHerbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, CA, USA.
Britta A LarsenHerbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, CA, USA.
Borja SañudoPhysical Education and Sports Department, University of Seville, Seville, Spain.
Natalie M YarishExercise Science, Old Dominion University, Norfolk, VA, USA.
Sonia JainBiostatistics Research Center, Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, USA.
Job G GodinoHerbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, CA, USA.

Funding

Social Mobile Approaches to Reduce Weight (SMART) 2.0R01HL136769 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HEKLER, ERIC · 2018 to 2022
$3.7M
Reducing social isolation and loneliness through physical activity to lower cardiovascular disease risk among military women and men reintegrating into civilian lifeK01HL159348 · NHLBI · OLD DOMINION UNIVERSITY · PI Natalie Marie Yarish · 2022 to 2026
$771k
NHLBI NIH HHS K01 HL159348NHLBI NIH HHS L30 HL148938NHLBI NIH HHS R01 HL136769
6 · The paper itself

Abstract

introductionThis study examines how physical activity intensity, body mass index (BMI), and grip strength interact with bone health indicators-specifically areal bone mineral density (BMD) and Trabecular Bone Score (TBS)-in young adults with overweight and obesity. This research aims to clarify these relationships to inform effective physical activity interventions for this demographic.

methodsData from 638 young adults (aged 18-35 years) participating in a weight loss randomized clinical trial was analyzed. Multiple Linear Regression (MLR) was utilized to assess the impact of physical activity, BMI, and grip strength on BMD and TBS.

resultsSignificant correlations were found between femoral neck BMD and age (β = -0.0056, p < 0.001), BMI (β = 0.0140, p < 0.001), grip strength (β = 0.2865, p < 0.001), light physical activity (β = 0.0002, p < 0.01) and moderate-to-vigorous physical activity (MVPA) (β = 0.0006, p < 0.01) physical activity intensities. Total hip BMD showed similar associations. Analyses of spine BMD and mean TBS highlighted the positive impacts of BMI and grip strength, with light physical activity also benefiting TBS. DISCUSSION: The study confirms the beneficial effects of light activity and MVPA on femoral neck and total hip BMD, challenging the traditional perception that higher body weight positively impacts bone health by revealing a negative correlation between BMI and TBS. Grip strength's consistent association with better bone health outcomes underlines the critical role of muscular strength.

Indexed as

Bone DensityCancellous BoneExerciseObesityOverweightAdolescentAdultBody Mass IndexFemaleHand StrengthHumansMaleYoung Adult

Identifiers

PMID40610757
PMCPMC13235530

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.