Evidence map›Paper›PMID 40610697›Full record

ArticleMolecular imaging and biology2025

Positive Protective Effects of Sigma-1 Receptor Stimulation with Fluvoxamine after Myocardial Ischemia and Reperfusion in Rats.

Xue Zhang, Hiroshi Wakabayashi, Hiroshi Mori, Tomo Hiromasa, Zhuoqing Chen, Takashi Kozaka, Kazuma Ogawa, Seigo Kinuya, Junichi Taki

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular imaging and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xue ZhangDepartment of Nuclear Medicine, Kanazawa University Hospital, 13-1 Takara-Machi, Kanazawa, Ishikawa, Japan.
Hiroshi WakabayashiDepartment of Nuclear Medicine, Kanazawa University Hospital, 13-1 Takara-Machi, Kanazawa, Ishikawa, Japan. wakabayashi@staff.kanazawa-u.ac.jp.ORCID 0000-0002-4942-6470
Hiroshi MoriDepartment of Nuclear Medicine, Kanazawa University Hospital, 13-1 Takara-Machi, Kanazawa, Ishikawa, Japan.
Tomo HiromasaDepartment of Nuclear Medicine, Kanazawa University Hospital, 13-1 Takara-Machi, Kanazawa, Ishikawa, Japan.
Zhuoqing ChenDepartment of Nuclear Medicine, Kanazawa University Hospital, 13-1 Takara-Machi, Kanazawa, Ishikawa, Japan.
Takashi KozakaDivision of Probe Chemistry for Disease Analysis, Research Center for Experimental Modeling of Human Disease, Kanazawa University, 13-1 Takara-Machi, Kanazawa, Ishikawa, Japan.
Kazuma OgawaGraduate School of Medical Sciences, Kanazawa University, Kakuma-Machi, Kanazawa, Ishikawa, Japan.
Seigo KinuyaDepartment of Nuclear Medicine, Kanazawa University Hospital, 13-1 Takara-Machi, Kanazawa, Ishikawa, Japan.
Junichi TakiDepartment of Nuclear Medicine, Kanazawa University Hospital, 13-1 Takara-Machi, Kanazawa, Ishikawa, Japan.

Funding

Japan Science and Technology Agency JPMJFS2116Japan Science and Technology Corporation JPMJSP2135
6 · The paper itself

Abstract

backgroundThe sigma-1 receptor (Sig-1R) plays diverse roles in regulating Endoplasmic Reticulum (ER) stress, calcium handling, and ion channel activity under pathological conditions, offering cardioprotective effects in pressure overload-induced dysfunction. However, its role in post-myocardial ischemia damage remains unclear. This study evaluated the cardioprotective effects of Sig-1R activation by fluvoxamine following myocardial ischemia in rats. METHOD AND

resultsWistar rats underwent 20 min of coronary artery occlusion followed by reperfusion. Rats received either saline (control) or fluvoxamine for two weeks. ECG-gated SPECT with

conclusionsSig-1R stimulation by fluvoxamine suppresses LV remodelling and enhances LVEF recovery post-ischemia, suggesting its potential as a novel cardioprotective strategy.

Indexed as

Cardiotonic AgentsFluvoxamineMyocardial IschemiaMyocardial Reperfusion InjuryReceptors, sigmaAnimalsAutoradiographyMaleMyocardiumRatsRats, WistarSigma-1 ReceptorTomography, Emission-Computed, Single-PhotonVentricular Function, LeftCardiotonic AgentsFluvoxamineReceptors, sigmaSigma-1 Receptor125I-OI5VFluvoxamineIschemiaSigma-1 receptor

Identifiers

PMID40610697
PMCPMC12405349

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.